{"id":"W2979503599","doi":"10.1128/aac.01744-19","title":"Quinazoline-Based Antivirulence Compounds Selectively Target <i>Salmonella</i> PhoP/PhoQ Signal Transduction System","year":2019,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Engineering and Physical Sciences Research Council; University of North Carolina at Chapel Hill; Biocenter Finland; Ministerio de Ciencia, Tecnología e Innovación Productiva; Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation; Consejo Nacional de Investigaciones Científicas y Técnicas; CYTED Ciencia y Tecnología para el Desarrollo; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Agencia Nacional de Promoción Científica y Tecnológica; Wellcome Trust; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Novartis Pharma; China Scholarship Council; Pfizer","keywords":"Salmonella; Bacteria; Signal transduction; Transduction (biophysics); Pathogenic bacteria; Microbiology; Biology; Cell biology; Chemistry; Genetics; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008429382,0.000337376,0.0002610056,0.0001632768,0.0001273197,0.0002196447,0.000339997,0.0002257467,0.002215644],"category_scores_gemma":[0.0000852337,0.00009520225,0.0001871054,0.00009908676,0.0001936204,0.000226556,0.0001941793,0.0005345986,0.0005185014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002103511,"about_ca_system_score_gemma":0.0001459142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004697944,"about_ca_topic_score_gemma":0.0007846147,"domain_scores_codex":[0.9999331,0.00001092353,0.00000367431,0.00001303143,0.0000162807,0.00002291401],"domain_scores_gemma":[0.999963,0.000005897421,0.000009969021,0.000002786983,0.00001064115,0.00000770208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001899144,0.00005288508,0.0001579978,0.0002788259,0.00001043439,0.0001055779,0.00001156535,0.0001985008,0.988791,0.0003876779,0.0005863266,0.009229245],"study_design_scores_gemma":[0.0001113038,0.001575051,0.002735599,0.00003101816,0.00003285777,0.0005384385,0.00002835998,0.001303156,0.9778585,0.0001726323,0.01559467,0.00001848586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9182105,0.04427985,0.01327812,0.001081162,0.0003138996,0.0003042091,0.0008984344,0.0006805497,0.0209532],"genre_scores_gemma":[0.9857282,0.007904309,0.00209751,0.0003257408,0.00003224954,0.00005130703,0.0003083061,0.00001729639,0.003535059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002215644,"threshold_uncertainty_score":0.007412076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005283717746734667,"score_gpt":0.2127741272249627,"score_spread":0.207490409478228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}