{"id":"W2979511540","doi":"10.1182/blood.v128.22.1573.1573","title":"Leveraging Increased Nucleoside Kinase Activity to Selectively Deplete Mitochondrial DNA (mtDNA), Impair Oxidative Phosphorylation, and Target AML Cells","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"","keywords":"Deoxycytidine kinase; Biology; TFAM; Molecular biology; Mitochondrial biogenesis; Gene knockdown; Mitochondrial DNA; Mitochondrion; Kinase; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009314398,0.0002768581,0.0002819822,0.0001552621,0.0001132553,0.0003774416,0.0001609012,0.0002073032,0.0013811],"category_scores_gemma":[0.00008135314,0.00009676874,0.0001584057,0.0001369942,0.0001548243,0.0001466834,0.0001860284,0.0004991031,0.0003689595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002204237,"about_ca_system_score_gemma":0.0001807411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005634188,"about_ca_topic_score_gemma":0.001190425,"domain_scores_codex":[0.999877,0.000008512019,0.0000168235,0.00003451674,0.00003900673,0.000024199],"domain_scores_gemma":[0.9999378,0.00001261291,0.00001497444,0.000008736707,0.000008104898,0.00001772144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004641193,0.00002269616,0.0001300843,0.00002807685,0.000003519203,0.00001520671,0.00001063161,0.00007552001,0.9982286,0.00008263932,0.00006105378,0.001295465],"study_design_scores_gemma":[0.00001081245,0.0001954529,0.001422096,0.000002739479,0.00001229187,0.00006785603,0.00001236635,0.0006189857,0.9946608,0.00002637052,0.002968429,0.000001822813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893363,0.00147837,0.00512446,0.0001714952,0.00007608658,0.0001117124,0.001349889,0.0002570174,0.002094741],"genre_scores_gemma":[0.9898632,0.0007191164,0.004476242,0.00007329714,0.000009380126,0.00009530992,0.0009489775,0.00002880072,0.003785863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0013811,"threshold_uncertainty_score":0.004620254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007825503350334276,"score_gpt":0.2148959840198638,"score_spread":0.2070704806695295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}