{"id":"W2979513542","doi":"10.1182/blood.v118.21.1693.1693","title":"Combination Targeted Therapy to Impair Self-Renewal Capacity of Human Blast Crisis Leukemia Stem Cells","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Dasatinib; Progenitor cell; Bone marrow; Medicine; CD34; Population; Stem cell; Haematopoiesis; Immunology; Cancer research; Internal medicine; Myeloid leukemia; Biology; Imatinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001258983,0.0003021861,0.0003984738,0.0002112451,0.00007900232,0.0002394381,0.0001949962,0.0001996592,0.001855887],"category_scores_gemma":[0.00006797595,0.00007906578,0.0001657164,0.0001696634,0.0001059686,0.0001209494,0.0001456194,0.000475769,0.0004155025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001734541,"about_ca_system_score_gemma":0.000197236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002960339,"about_ca_topic_score_gemma":0.0008709976,"domain_scores_codex":[0.9999012,0.0000162959,0.00001033898,0.00001647448,0.00003367238,0.00002205142],"domain_scores_gemma":[0.9999729,0.000005225475,0.000006792477,0.000004913043,0.000003186717,0.000006890343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007950229,0.0005017534,0.0006005607,0.0001158813,0.00003831232,0.00009741962,0.00002826649,0.0006603271,0.9748488,0.0003147258,0.0006092031,0.0213897],"study_design_scores_gemma":[0.0005539802,0.01127443,0.01002234,0.00001443497,0.0001194572,0.00110548,0.00004238694,0.003226331,0.9599552,0.0001413713,0.01353092,0.00001362981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932796,0.002230628,0.001606446,0.00009669935,0.00005178847,0.0001313171,0.0003279925,0.00008905882,0.002186555],"genre_scores_gemma":[0.9959713,0.001035408,0.000972776,0.00004572608,0.00001498712,0.00007076435,0.0004427912,0.000007604351,0.001438647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001855887,"threshold_uncertainty_score":0.006208539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03020615455161841,"score_gpt":0.2469144384285916,"score_spread":0.2167082838769732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}