{"id":"W2979515484","doi":"10.1634/theoncologist.2019-0446","title":"De Novo Versus Recurrent HER2-Positive Metastatic Breast Cancer: Patient Characteristics, Treatment, and Survival from the SystHERs Registry","year":2019,"lang":"en","type":"article","venue":"The Oncologist","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Medicine; Metastatic breast cancer; Hazard ratio; Internal medicine; Breast cancer; Pertuzumab; Clinical endpoint; Oncology; Proportional hazards model; Metastasis; Trastuzumab; Confidence interval; Cancer; Chemotherapy; Cancer registry; Progression-free survival; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001325871,0.0001293426,0.0003310498,0.0007798608,0.0002378583,0.0004039857,0.0003351699,0.0002389255,0.002147414],"category_scores_gemma":[0.002866742,0.0001387272,0.0003291038,0.001417314,0.000180824,0.0004765999,0.0004749317,0.0003248933,0.000335167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003645016,"about_ca_system_score_gemma":0.0005378384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0023752,"about_ca_topic_score_gemma":0.00478413,"domain_scores_codex":[0.9991198,0.0002042457,0.0001639284,0.0002402924,0.0001910088,0.00008073019],"domain_scores_gemma":[0.996768,0.0006398803,0.001979072,0.0001981727,0.0002263734,0.0001886266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004385162,0.00004113399,0.9960748,0.00003139206,0.00007211155,0.00005526701,0.00005129798,0.00007580194,0.0001507982,0.00004630724,0.00110837,0.001854338],"study_design_scores_gemma":[0.00009668335,0.0001983006,0.9970707,0.00002534329,0.0001008947,0.0004676492,0.0001218698,0.0002718561,0.0001464837,0.00004323535,0.001449311,0.000007697166],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889212,0.0003869663,0.000127009,0.0001100696,0.000004537922,0.00003054951,0.009556524,0.000007509404,0.0008557492],"genre_scores_gemma":[0.9822,0.0003237075,0.0002195198,0.0001070946,0.00002308315,0.0001062876,0.01674188,0.000007563648,0.0002708446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0023752,"threshold_uncertainty_score":0.00718379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05891216506106133,"score_gpt":0.3761415138606755,"score_spread":0.3172293487996141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}