{"id":"W2979529073","doi":"10.1038/s41467-019-12482-1","title":"TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Civil, Mechanical and Manufacturing Innovation; Division of Chemical, Bioengineering, Environmental, and Transport Systems; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Foundation for the National Institutes of Health; Academy of Finland; University of California, San Francisco; National Eye Institute; Sydäntutkimussäätiö; National Heart, Lung, and Blood Institute; Foundation for Cardiovascular Research; National Institutes of Health; National Science Foundation","keywords":"Cardiolipin; Beta oxidation; Mitochondrion; Cell biology; Biochemistry; Chemistry; Fatty acid; Downregulation and upregulation; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001156181,0.0001659489,0.0001590793,0.0001299665,0.0001473359,0.0002339968,0.000100245,0.0002015071,0.001313013],"category_scores_gemma":[0.0001819859,0.0001163657,0.0001802226,0.00007178917,0.0001693218,0.00008286956,0.0001810315,0.000254377,0.0006438574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001198435,"about_ca_system_score_gemma":0.0001748395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003163226,"about_ca_topic_score_gemma":0.0004141368,"domain_scores_codex":[0.9999104,0.00001071914,0.00001164262,0.00002849032,0.00002399452,0.00001478921],"domain_scores_gemma":[0.9998368,0.00002775609,0.00005410705,0.00001803401,0.0000126202,0.0000506695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007334462,0.000006369699,0.0003602729,0.00001630307,0.000004288486,0.0002244416,0.000009018286,0.0000380072,0.9984225,0.00005113233,0.00003396352,0.0007604312],"study_design_scores_gemma":[0.00003675898,0.0001656904,0.01806334,0.00001132448,0.00002862292,0.002498423,0.0000614247,0.001847025,0.9742759,0.0001250054,0.00287846,0.000008145988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938737,0.0006237232,0.003939598,0.00009790548,0.00003658523,0.00001453668,0.0007061748,0.0001337786,0.0005739373],"genre_scores_gemma":[0.9971853,0.0001544085,0.001207294,0.00003718356,0.000007209249,0.00001216136,0.0006149068,0.00003458615,0.0007468457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001313013,"threshold_uncertainty_score":0.004392445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03737681345072644,"score_gpt":0.3186165003089157,"score_spread":0.2812396868581892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}