{"id":"W2979530151","doi":"10.1182/blood.v128.22.2873.2873","title":"Discovery and Validation of Cell-Surface Protein Mesothelin (MSLN) As a Novel Therapeutic Target in AML: Results from the COG/NCI Target AML Initiative","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Occupational and environmental lung diseases","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Canada's Michael Smith Genome Sciences Centre","funders":"","keywords":"Mesothelin; Cancer research; Biology; Haematopoiesis; Cancer; Stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001011291,0.0003814972,0.0006208834,0.0006189579,0.0003797774,0.0007884506,0.0003661568,0.0005160565,0.0008402654],"category_scores_gemma":[0.0005993876,0.0001109731,0.0004269864,0.0007619932,0.0002687615,0.0001845821,0.0005230244,0.0004501409,0.0003974559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007786055,"about_ca_system_score_gemma":0.0009869551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002505746,"about_ca_topic_score_gemma":0.002994656,"domain_scores_codex":[0.9995502,0.00004455274,0.00002261219,0.00008075973,0.000244949,0.00005693238],"domain_scores_gemma":[0.9996585,0.00005354685,0.00004418987,0.00002688194,0.0001384117,0.00007858757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00146034,0.0003249927,0.03013338,0.0004728515,0.0001621996,0.000226682,0.00009095717,0.003552782,0.9057942,0.0004439648,0.005641883,0.05169583],"study_design_scores_gemma":[0.0005120152,0.001896341,0.1725519,0.0001189669,0.0006953705,0.001125531,0.0003175309,0.03196098,0.7158055,0.001053205,0.07389693,0.00006573236],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.958796,0.006487145,0.006901395,0.0007533355,0.00006838117,0.0002960185,0.02289902,0.0005853117,0.003213307],"genre_scores_gemma":[0.8923731,0.003121691,0.03512863,0.000925202,0.00003583002,0.0002477349,0.06610492,0.0001411092,0.001921814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002505746,"threshold_uncertainty_score":0.005649149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01705921486465569,"score_gpt":0.2406104842126991,"score_spread":0.2235512693480435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}