{"id":"W2979532361","doi":"10.1182/blood.v112.11.822.822","title":"Immunosuppression Modulates Immune Responses to AAV Capsid in Human Subjects Undergoing Intramuscular Gene Transfer for Lipoprotein Lipase Deficiency","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Chicoutimi; Université de Montréal","funders":"","keywords":"Genetic enhancement; Immunology; Immunosuppression; Immune system; ELISPOT; Lipoprotein lipase; Biology; Medicine; CD8; Internal medicine; Gene; Adipose tissue","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003106816,0.0003487354,0.0005072322,0.0002874317,0.000477084,0.0003699749,0.00009073687,0.0004534578,0.001009685],"category_scores_gemma":[0.0006172804,0.0002264562,0.0001596978,0.0001866887,0.00034438,0.0001296716,0.0001270296,0.0004330185,0.0002552136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001968035,"about_ca_system_score_gemma":0.0001215961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006974725,"about_ca_topic_score_gemma":0.0006211592,"domain_scores_codex":[0.9998639,0.00005122608,0.000008716105,0.00002722626,0.00001625706,0.0000327825],"domain_scores_gemma":[0.9997509,0.00006589479,0.00005442158,0.00001727585,0.00002429128,0.00008709277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01954775,0.008026063,0.6321414,0.0001858798,0.0001193461,0.01497875,0.003019405,0.0003313025,0.2922228,0.0001793632,0.0006114837,0.0286365],"study_design_scores_gemma":[0.0006267554,0.04253861,0.9342528,0.00002253912,0.0001454113,0.008921028,0.0008192452,0.0009004044,0.0104254,0.0001123241,0.001207915,0.00002763168],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996951,0.00006729541,0.00004120998,0.00001181984,0.000003558956,0.00001337036,0.000005978403,0.000002512511,0.00015917],"genre_scores_gemma":[0.9997026,0.00003843361,0.00003407527,0.00002796438,0.00001068395,0.0000109506,0.00001498126,0.00000109764,0.0001591488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001009685,"threshold_uncertainty_score":0.003377676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0193407967844535,"score_gpt":0.2809671073335194,"score_spread":0.2616263105490659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}