{"id":"W2979548369","doi":"10.1016/s1470-2045(19)30493-0","title":"Patient-reported quality of life after tisagenlecleucel infusion in children and young adults with relapsed or refractory B-cell acute lymphoblastic leukaemia: a global, single-arm, phase 2 trial","year":2019,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Cancer Institute; Novartis","keywords":"Medicine; Refractory (planetary science); Quality of life (healthcare); Young adult; Pediatrics; Oncology; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009309913,0.001379468,0.002090033,0.0002568455,0.0002544386,0.001008498,0.0006426987,0.001198532,0.002319622],"category_scores_gemma":[0.000870003,0.0003348789,0.001952372,0.0003899472,0.001060991,0.0007895973,0.0005760089,0.003079691,0.0004562294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009107757,"about_ca_system_score_gemma":0.000837494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001110141,"about_ca_topic_score_gemma":0.002393512,"domain_scores_codex":[0.9995087,0.0002459402,0.000020697,0.00008651296,0.00003426792,0.0001037141],"domain_scores_gemma":[0.9993278,0.0001247383,0.0001836821,0.00003536265,0.00002598346,0.0003024834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9151657,0.0102226,0.01270887,0.0009306439,0.003507338,0.0001881056,0.0002521569,0.001176596,0.004028149,0.0002341597,0.002437134,0.04914854],"study_design_scores_gemma":[0.7866395,0.1610302,0.04670837,0.00009702931,0.001520897,0.0002698981,0.0001546709,0.0008170817,0.0007984304,0.0002634039,0.001655977,0.00004447459],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959036,0.002214564,0.0001028574,0.0003407612,0.00006118217,0.0002475122,0.0006440788,0.00003124838,0.0004542086],"genre_scores_gemma":[0.9945673,0.001587734,0.0003412243,0.0005831297,0.00009301148,0.0008419272,0.001159238,0.00001168868,0.0008147726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002319622,"threshold_uncertainty_score":0.007759929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03486376564826552,"score_gpt":0.345367385747986,"score_spread":0.3105036200997205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}