{"id":"W2979579934","doi":"10.1158/0008-5472.can-19-1961","title":"Upregulation of Myt1 Promotes Acquired Resistance of Cancer Cells to Wee1 Inhibition","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Northern Alberta Institute of Technology; Alberta Cancer Foundation; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Downregulation and upregulation; Wee1; Cancer; Biology; Cancer research; Cell cycle; Genetics; Gene; Cyclin-dependent kinase 1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007574821,0.00015945,0.0001988455,0.0001497464,0.00009584899,0.0002533628,0.0001088755,0.0001927609,0.001251565],"category_scores_gemma":[0.0001004049,0.00009653594,0.0001532692,0.00009242034,0.0001327074,0.0001338228,0.0001538397,0.0004061197,0.0002847451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002464292,"about_ca_system_score_gemma":0.0001367257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003311454,"about_ca_topic_score_gemma":0.0005113186,"domain_scores_codex":[0.9999256,0.000007187896,0.00000718974,0.00001875432,0.00002078019,0.00002054638],"domain_scores_gemma":[0.9999444,0.000009332223,0.00001932129,0.000005577715,0.000007399849,0.00001397319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004880349,0.00001723174,0.0002562364,0.00002003646,0.000002804068,0.00002498643,0.000006261859,0.00004829756,0.9986942,0.00004536634,0.00002907727,0.0008065961],"study_design_scores_gemma":[0.00001232804,0.0002079137,0.008713333,0.000004742523,0.000009617554,0.0002443683,0.00002377675,0.001103989,0.9878714,0.00002855861,0.001777115,0.000002704374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962797,0.0008326065,0.001438549,0.00006474937,0.00001556471,0.00002291418,0.0003013597,0.00006860453,0.0009759667],"genre_scores_gemma":[0.9974639,0.0003166283,0.0007593911,0.00002388866,0.000002820456,0.00001894955,0.0002862703,0.000006908778,0.001121117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001251565,"threshold_uncertainty_score":0.004186928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02106708494762495,"score_gpt":0.3901589490972172,"score_spread":0.3690918641495923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}