{"id":"W2979601009","doi":"10.1038/s41564-019-0583-6","title":"Evasion of autophagy mediated by Rickettsia surface protein OmpB is critical for virulence","year":2019,"lang":"en","type":"article","venue":"Nature Microbiology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; NIH Office of the Director; U.S. Department of Health and Human Services; National Institutes of Health; Fonds de recherche du Québec – Nature et technologies; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Howard Hughes Medical Institute","keywords":"Autophagy; Cell biology; Biology; Microbiology; Intracellular parasite; Cytosol; Bacterial outer membrane; Intracellular; Gene; Apoptosis; Biochemistry; Escherichia coli","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001706865,0.0001844426,0.0004667153,0.00005370105,0.00003374875,0.000003486736,0.0001630104,0.0007866655,0.0007955403],"category_scores_gemma":[0.0002028298,0.0001450285,0.0001490042,0.0001387513,0.0001658424,0.00003877238,0.000034963,0.0004396278,0.00013235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000378209,"about_ca_system_score_gemma":0.0001178766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006615364,"about_ca_topic_score_gemma":4.532806e-7,"domain_scores_codex":[0.9988589,0.00006776667,0.0002783925,0.0003887933,0.00007902812,0.0003271095],"domain_scores_gemma":[0.9990154,0.0002603821,0.00009060275,0.0003257119,0.0002155464,0.00009236485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006554347,0.00020185,0.0005911073,0.0002024701,0.0000774066,0.000005492822,0.00005171031,2.245044e-7,0.9809105,0.0006586637,0.01644369,0.0002014168],"study_design_scores_gemma":[0.002367458,0.0007335004,0.001013775,0.0001110667,0.0000571836,0.00003653498,0.00002044907,0.00007197338,0.9508997,0.0002970129,0.04423839,0.0001529259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870234,0.008690845,0.0001337923,0.00189479,0.000280332,0.001132084,0.0005508545,0.00005535383,0.0002385155],"genre_scores_gemma":[0.9937557,0.00004833568,0.001257223,0.003313275,0.00006142573,0.00002037353,0.0003815125,0.00002650657,0.001135639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0300108,"threshold_uncertainty_score":0.8710608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005336277062289684,"score_gpt":0.2928231302015011,"score_spread":0.2874868531392114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}