{"id":"W2979601009","doi":"10.1038/s41564-019-0583-6","title":"Evasion of autophagy mediated by Rickettsia surface protein OmpB is critical for virulence","year":2019,"lang":"en","type":"article","venue":"Nature Microbiology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; NIH Office of the Director; U.S. Department of Health and Human Services; National Institutes of Health; Fonds de recherche du Québec – Nature et technologies; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Howard Hughes Medical Institute","keywords":"Autophagy; Cell biology; Biology; Microbiology; Intracellular parasite; Cytosol; Bacterial outer membrane; Intracellular; Gene; Apoptosis; Biochemistry; Escherichia coli","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002895493,0.000404073,0.0005088286,0.0003065118,0.0004163996,0.0007159311,0.0001834995,0.0006428711,0.002040841],"category_scores_gemma":[0.0002237052,0.0001841566,0.0004349424,0.0001451371,0.0004094546,0.0003192918,0.0006634548,0.001004382,0.001389848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005197932,"about_ca_system_score_gemma":0.0003906795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002158393,"about_ca_topic_score_gemma":0.0003440219,"domain_scores_codex":[0.9996305,0.00006012979,0.00002995515,0.00004566038,0.00009766769,0.0001360847],"domain_scores_gemma":[0.9997906,0.00001462155,0.0000596321,0.00002532108,0.00004366678,0.00006628345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005121342,0.00005590804,0.0008992776,0.00009699128,0.00001342101,0.0002231239,0.00001918334,0.00008020763,0.9941171,0.0006838267,0.0005753625,0.00272346],"study_design_scores_gemma":[0.0001341287,0.0008872684,0.048878,0.00007042589,0.00002981844,0.002405381,0.0003623904,0.002784368,0.9265243,0.00124037,0.01664729,0.00003634111],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797361,0.008945568,0.003429028,0.001370599,0.0002581881,0.00004583,0.000625735,0.0002749325,0.005313974],"genre_scores_gemma":[0.9939423,0.001266502,0.001339949,0.0001427524,0.00003570954,0.000027352,0.0006802144,0.00003818858,0.002526951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002040841,"threshold_uncertainty_score":0.006827295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005336277062289684,"score_gpt":0.2928231302015011,"score_spread":0.2874868531392114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}