{"id":"W2979604098","doi":"10.1016/j.celrep.2019.08.105","title":"Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Terry Fox Research Institute; Canadian HIV Trials Network, Canadian Institutes of Health Research; Canada Research Chairs; U.S. Department of Defense","keywords":"Trastuzumab; Cancer research; Immunotherapy; Interferon; Biology; EZH2; Reprogramming; Breast cancer; PRC2; Histone; Immunology; Cancer; Medicine; Immune system; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001254318,0.0002129592,0.0002550923,0.0001497927,0.0001532057,0.0002281199,0.0002140612,0.0002078159,0.002510651],"category_scores_gemma":[0.00009913997,0.0001028149,0.0001484745,0.0001636004,0.0001726035,0.0001601532,0.0001635709,0.0006363653,0.000319797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002504789,"about_ca_system_score_gemma":0.0001756911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007862187,"about_ca_topic_score_gemma":0.002242501,"domain_scores_codex":[0.9999014,0.0000133319,0.000004980475,0.00001519967,0.00002628956,0.00003864142],"domain_scores_gemma":[0.9999688,0.000006333022,0.00000524454,0.000004733544,0.000003327035,0.00001160232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006223831,0.0001990472,0.0002387032,0.00005893861,0.00002359345,0.00003415317,0.0000204772,0.0003183342,0.9907368,0.0001358984,0.0004981217,0.007113559],"study_design_scores_gemma":[0.0001764299,0.001588616,0.006579409,0.000008460431,0.00004689232,0.0002168536,0.00003927064,0.001875421,0.9842811,0.00008981573,0.005091519,0.00000613748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916239,0.002763495,0.001544127,0.0001853343,0.00005947646,0.00004117964,0.0003724946,0.0001012551,0.003308693],"genre_scores_gemma":[0.995782,0.0008181842,0.0005120849,0.00005744163,0.000008307545,0.00003310688,0.000291701,0.00001581607,0.002481367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002510651,"threshold_uncertainty_score":0.00839889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01577806620548678,"score_gpt":0.3036998077914299,"score_spread":0.2879217415859431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}