{"id":"W2979606780","doi":"10.1016/s2468-1253(19)30320-6","title":"Safety of two different doses of simvastatin plus rifaximin in decompensated cirrhosis (LIVERHOPE-SAFETY): a randomised, double-blind, placebo-controlled, phase 2 trial","year":2019,"lang":"en","type":"article","venue":"The Lancet. Gastroenterology & hepatology","topic":"Liver Disease and Transplantation","field":"Medicine","cited_by":145,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Horizon 2020 Framework Programme; Grifols; Intercept Pharmaceuticals; Gilead Sciences; Horizon 2020; Instituto de Salud Carlos III; Spanish Clinical Research Network; Pfizer","keywords":"Rifaximin; Medicine; Simvastatin; Placebo; Double blind; Cirrhosis; Internal medicine; Gastroenterology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008142171,0.0004396481,0.003101434,0.0004278827,0.00006118335,0.000007689497,0.0003812618,0.0002198581,0.0004641046],"category_scores_gemma":[0.00002455575,0.0003155629,0.0004822982,0.0002103351,0.0003725235,0.00008642581,0.00007919804,0.0005062284,0.00002816102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001200998,"about_ca_system_score_gemma":0.000192264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004215271,"about_ca_topic_score_gemma":0.00183201,"domain_scores_codex":[0.9955237,0.001091013,0.00168689,0.0005910903,0.0003196138,0.0007877084],"domain_scores_gemma":[0.9971798,0.001031994,0.0007954141,0.0006663349,0.0001626883,0.000163737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7882494,0.001005546,0.2052217,0.0001900304,0.001411132,0.00009371427,0.0005784238,0.0001752983,0.002725016,0.0001188662,0.00003896691,0.0001918209],"study_design_scores_gemma":[0.9758796,0.003971322,0.01250676,0.0001454896,0.001899049,0.00012455,0.0001522768,0.003942976,0.001136478,0.00006125055,0.00003112587,0.0001491252],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913908,0.0001682099,0.0009808943,0.0009101305,0.0005561584,0.005459095,0.0001788555,0.00004215223,0.0003136607],"genre_scores_gemma":[0.9979805,0.0003388151,0.0001040145,0.0006417044,0.0001629934,0.0003512909,0.0003383859,0.00003553332,0.00004676227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.192715,"threshold_uncertainty_score":0.9999297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02888913664553694,"score_gpt":0.311672063742598,"score_spread":0.2827829270970611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}