{"id":"W2979623390","doi":"10.1186/s13059-019-1818-9","title":"Global impact of somatic structural variation on the DNA methylome of human cancers","year":2019,"lang":"en","type":"article","venue":"Genome biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"National Cancer Institute; National Human Genome Research Institute; National Institutes of Health","keywords":"Biology; DNA methylation; Genetics; Epigenetics; Methylation; CpG site; Gene; Epigenomics; Methyltransferase; Copy-number variation; Genome; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002598872,0.0001569704,0.0003094436,0.0009868405,0.000177867,0.0003202641,0.0002012145,0.0002490836,0.001926573],"category_scores_gemma":[0.0008459448,0.00008863219,0.0002450676,0.0009271575,0.0002916346,0.0002030506,0.0004605752,0.0002377862,0.0001947632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00026115,"about_ca_system_score_gemma":0.000183411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001184387,"about_ca_topic_score_gemma":0.001822337,"domain_scores_codex":[0.9997178,0.00003884277,0.00001593423,0.0001365146,0.00005738169,0.0000335616],"domain_scores_gemma":[0.9995598,0.0001364616,0.0001349043,0.00006000936,0.00004619033,0.00006259488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000977173,0.00004187153,0.5711247,0.0003749227,0.0007660197,0.0002266208,0.0002205634,0.001776161,0.3828792,0.0004737072,0.0003117855,0.04082735],"study_design_scores_gemma":[0.000005924151,0.0001477046,0.9840789,0.0000122772,0.0001767712,0.000524469,0.00007030788,0.0007977232,0.01290383,0.0004218456,0.0008513352,0.000008923976],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931753,0.002057774,0.00158857,0.0000729609,0.00000525926,0.00001215483,0.002113674,0.00005715892,0.0009172689],"genre_scores_gemma":[0.9976037,0.00044393,0.0007022466,0.00002757198,0.000007831807,0.000008425854,0.001051968,0.00001026941,0.0001440409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001926573,"threshold_uncertainty_score":0.00644505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01148547559269623,"score_gpt":0.302772444721614,"score_spread":0.2912869691289178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}