{"id":"W2979642205","doi":"10.1182/blood.v124.21.899.899","title":"Targeting TKI-Insensitive CML Stem/Progenitor Cells By Effective Inhibition of a Novel PP2A-AHI-1-BCR-ABL-JAK2 Complex","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Beetle Biology and Toxicology Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Stem cell; Progenitor cell; Imatinib mesylate; Cancer research; Tyrosine kinase; Medicine; Biology; Imatinib; Cell biology; Signal transduction; Myeloid leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002801739,0.000216375,0.0003129144,0.00003289187,0.0001511879,0.000005808109,0.00009264874,0.0003258127,0.000005677931],"category_scores_gemma":[0.00009007442,0.0002019641,0.0001120418,0.00006902565,0.0002999732,0.000003622976,0.0001388341,0.0001250177,0.000009419658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008257242,"about_ca_system_score_gemma":0.0000224236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001339247,"about_ca_topic_score_gemma":0.00001042053,"domain_scores_codex":[0.9987574,0.0001902638,0.0002592023,0.000418827,0.00008439509,0.0002899537],"domain_scores_gemma":[0.9993183,0.00008839567,0.0001900763,0.0002023289,0.0001428184,0.00005810757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009866479,0.0005452881,0.002569767,0.0000323734,0.0003189087,0.000002044593,0.00006423105,0.000003993769,0.9936357,0.00009134994,0.002325878,0.0003118591],"study_design_scores_gemma":[0.002344655,0.0008552938,0.001961739,0.00001642606,0.0001145713,0.00001288123,0.0001188882,0.00003687487,0.9902027,0.00002184292,0.004091725,0.0002224319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967688,0.0006248055,0.0009548859,0.00006691267,0.0001861655,0.0003834664,0.0001489188,0.00002092268,0.000845066],"genre_scores_gemma":[0.9982024,0.00004300731,0.0007551333,0.0003048486,0.0003000683,0.00005558214,0.0001966782,0.00002105527,0.0001211815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00343297,"threshold_uncertainty_score":0.8235857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009288060313120095,"score_gpt":0.224045848324638,"score_spread":0.2147577880115179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}