{"id":"W2979643211","doi":"10.1182/blood.v118.21.480.480","title":"Vantage 095: Vorinostat in Combination with Bortezomib in Salvage Multiple Myeloma Patients: Final Study Results of a Global Phase 2b Trial","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Bortezomib; Multiple myeloma; Regimen; Vorinostat; Clinical endpoint; Internal medicine; Phases of clinical research; Dexamethasone; Oncology; Salvage therapy; Refractory (planetary science); Gastroenterology; Progressive disease; Clinical trial; Combination therapy; Pharmacology; Chemotherapy; Histone deacetylase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001779134,0.001565002,0.001831535,0.0003222841,0.0002416119,0.00117882,0.0008487029,0.0008190727,0.003726138],"category_scores_gemma":[0.000785025,0.0004256946,0.001144968,0.0004653035,0.0006356085,0.000850712,0.0004612478,0.00242102,0.0009413891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001095829,"about_ca_system_score_gemma":0.001345562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001148919,"about_ca_topic_score_gemma":0.003191294,"domain_scores_codex":[0.9995741,0.000207096,0.00002407173,0.00007991491,0.00004226331,0.00007250276],"domain_scores_gemma":[0.9995518,0.00005937196,0.00008794678,0.00002539829,0.00003013468,0.0002452338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7098323,0.02525373,0.009797856,0.001321837,0.003768499,0.0003996952,0.0003166482,0.002898456,0.03694679,0.0004361028,0.01312521,0.1959029],"study_design_scores_gemma":[0.7919869,0.1839836,0.01457973,0.0001079437,0.0009522063,0.0003169192,0.0000604083,0.001009593,0.002447134,0.0002603838,0.004259466,0.00003552667],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785161,0.008579394,0.0005665547,0.001265529,0.0002181846,0.001925875,0.003619775,0.0002184163,0.005090123],"genre_scores_gemma":[0.974483,0.005714104,0.002060544,0.002155366,0.0002827167,0.002092076,0.008866386,0.00007201885,0.004273643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003726138,"threshold_uncertainty_score":0.01246512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04700091844040593,"score_gpt":0.3249367596965943,"score_spread":0.2779358412561884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}