{"id":"W2979656437","doi":"10.1182/blood.v108.11.1377.1377","title":"ENMD-981693 Is an Orally-Active Kinase Inhibitor with Activity towards Human Hematologic Cancers In Vitro and In Vivo.","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"","keywords":"Kinase; Aurora inhibitor; Tyrosine kinase; Cancer research; Ponatinib; Chronic myelogenous leukemia; Pharmacology; Dasatinib; Biology; Imatinib; Leukemia; Apoptosis; Cell cycle; Cell biology; Immunology; Biochemistry; Myeloid leukemia; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001162939,0.0005171295,0.0002868516,0.0002969695,0.0001091201,0.0001786262,0.0002536695,0.0002274772,0.002131758],"category_scores_gemma":[0.00006826287,0.0001355585,0.0001694498,0.0002805194,0.0001317129,0.0001273175,0.0001501967,0.0005557956,0.0006290924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000250508,"about_ca_system_score_gemma":0.0003252451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000468858,"about_ca_topic_score_gemma":0.001249144,"domain_scores_codex":[0.9999352,0.000009884007,0.000006820846,0.000009696736,0.00002578431,0.00001267012],"domain_scores_gemma":[0.9999733,0.000004772866,0.000007598559,0.000002597349,0.000003669709,0.000007988657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007971689,0.0004676858,0.0004324145,0.0002310155,0.00003404763,0.0002126089,0.000012636,0.0005906081,0.9726744,0.0003590564,0.0007079805,0.02348032],"study_design_scores_gemma":[0.001155306,0.006598322,0.007682276,0.00003795426,0.00005970491,0.00247448,0.00002589315,0.001492075,0.9501702,0.0001486331,0.03013772,0.00001737623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9608517,0.01694729,0.006468347,0.0003528321,0.0001691316,0.0004076399,0.003006779,0.0003253155,0.01147082],"genre_scores_gemma":[0.9726868,0.007932688,0.005494073,0.0001282978,0.00001914601,0.0001988194,0.006731839,0.00002030683,0.006787971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002131758,"threshold_uncertainty_score":0.007131457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01507091967790681,"score_gpt":0.2672596203174913,"score_spread":0.2521887006395845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}