{"id":"W2979675472","doi":"10.1182/blood.v104.11.2810.2810","title":"Proteasome Inhibiters Up-Regulate TRAIL/Apo2L and Its Receptors Significantly Contributing to Proteasome Inhibitor-Induced Apoptosis in Primary Chronic Lymphocytic Leukemia (CLL) Cells.","year":2004,"lang":"en","type":"article","venue":"Blood","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Proteasome; Apoptosis; Proteasome inhibitor; Chronic lymphocytic leukemia; Bortezomib; Cancer research; Annexin; Annexin A5; Receptor; Caspase 8; Biology; Leukemia; Caspase; Immunology; Programmed cell death; Multiple myeloma; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001293245,0.0002477393,0.000269818,0.0002184271,0.0001450343,0.0003279827,0.000070116,0.0001473184,0.001982116],"category_scores_gemma":[0.00009039057,0.0001118081,0.0002164144,0.0001657479,0.0001070576,0.0001308625,0.0001214017,0.0003874141,0.0005690693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004017469,"about_ca_system_score_gemma":0.0002606271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007843886,"about_ca_topic_score_gemma":0.001978096,"domain_scores_codex":[0.9998513,0.00001861046,0.0000147048,0.00001723318,0.00003900919,0.00005914579],"domain_scores_gemma":[0.9999191,0.00001558814,0.00001757948,0.00000952051,0.00001595453,0.00002231691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002160869,0.00005203242,0.0003359751,0.00004583978,0.00000647655,0.00006542924,0.00001240447,0.00001960346,0.9979243,0.00002289526,0.0001012793,0.001197701],"study_design_scores_gemma":[0.00008179162,0.0008253912,0.01465506,0.000008006705,0.00003143856,0.0003873128,0.00003792539,0.0004400352,0.9792958,0.00002796115,0.004204923,0.000004312412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913168,0.005364642,0.001009663,0.000115429,0.00005336391,0.00004325219,0.0005976518,0.00008570396,0.001413505],"genre_scores_gemma":[0.993107,0.001747409,0.0009529767,0.00008166955,0.0000237312,0.00005676415,0.0009676972,0.000009402415,0.003053282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001982116,"threshold_uncertainty_score":0.006630838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01030800477297293,"score_gpt":0.2147806984326608,"score_spread":0.2044726936596878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}