{"id":"W2979699646","doi":"10.1182/blood.v116.21.515.515","title":"BCR-ABL1 Kinase Activity but Not Its Expression Is Dispensable for Ph+ Quiescent Stem Cell Survival Which Depends on the PP2A-Controlled Jak2 Activation and Is Sensitive to FTY720 Treatment","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"CD38; Progenitor cell; Stem cell; Chronic myelogenous leukemia; CD34; Haematopoiesis; Tyrosine kinase; Cancer research; Biology; Imatinib mesylate; Cell biology; Chemistry; Leukemia; Immunology; Imatinib; Myeloid leukemia; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001023292,0.0002101873,0.000221587,0.0001591201,0.0001616806,0.0003373502,0.0001654936,0.0001813254,0.002264058],"category_scores_gemma":[0.00008503293,0.000127529,0.0001599164,0.0001038102,0.0001903583,0.0001579433,0.0001454603,0.0004420126,0.0005233882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003105536,"about_ca_system_score_gemma":0.0002047338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007244491,"about_ca_topic_score_gemma":0.0009467221,"domain_scores_codex":[0.9998776,0.00001455165,0.0000120135,0.00002083521,0.00004145173,0.00003346462],"domain_scores_gemma":[0.99989,0.00002321418,0.00002519417,0.00001410463,0.00001023328,0.00003734469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001115979,0.00002187827,0.0001041857,0.00001777532,0.000002117003,0.00004515031,0.000006051164,0.00002587863,0.9988704,0.0001122794,0.00005332319,0.0006292893],"study_design_scores_gemma":[0.00002623677,0.0002860131,0.00866074,0.000006326306,0.00001062318,0.0003709931,0.00002548719,0.0008071262,0.985993,0.00006127098,0.003748654,0.000003580409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937878,0.002035047,0.00086049,0.00009293708,0.00003337926,0.00002445538,0.0006267085,0.00006899775,0.002470135],"genre_scores_gemma":[0.9948225,0.0005344714,0.0003725201,0.00003301038,0.00001302348,0.00002378578,0.001041965,0.00001281977,0.003145905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002264058,"threshold_uncertainty_score":0.007574022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02486123472222202,"score_gpt":0.2680445943309308,"score_spread":0.2431833596087088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}