{"id":"W2979699646","doi":"10.1182/blood.v116.21.515.515","title":"BCR-ABL1 Kinase Activity but Not Its Expression Is Dispensable for Ph+ Quiescent Stem Cell Survival Which Depends on the PP2A-Controlled Jak2 Activation and Is Sensitive to FTY720 Treatment","year":2010,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"CD38; Progenitor cell; Stem cell; Chronic myelogenous leukemia; CD34; Haematopoiesis; Tyrosine kinase; Cancer research; Biology; Imatinib mesylate; Cell biology; Chemistry; Leukemia; Immunology; Imatinib; Myeloid leukemia; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002854029,0.0004366543,0.0006744285,0.00009129788,0.0003010989,0.00006150596,0.0000930871,0.0002065935,0.0001133393],"category_scores_gemma":[0.0001417671,0.0002732917,0.0001686905,0.0001551625,0.00002976891,0.0001285091,0.00007258732,0.0002691909,0.00005507905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004648951,"about_ca_system_score_gemma":0.0002829979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002880645,"about_ca_topic_score_gemma":0.0002129042,"domain_scores_codex":[0.9979559,0.0001214668,0.0002780461,0.0007011807,0.0004618965,0.0004814981],"domain_scores_gemma":[0.9978477,0.0007967732,0.0001925651,0.0006661497,0.0002142655,0.000282526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006709545,0.002612136,0.0007161777,0.00007368037,0.0003658096,0.00002384833,0.001573503,0.000003357447,0.9825145,0.0000370033,0.0004635462,0.004906913],"study_design_scores_gemma":[0.03873297,0.001520123,0.005322426,0.0001465779,0.0005908313,0.00001345221,0.0003524687,0.0005332271,0.9517434,0.000003564771,0.0008032029,0.0002377799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908637,0.00001849129,0.00006783073,0.003493963,0.000253406,0.003762091,0.0001825228,0.00005893413,0.001299021],"genre_scores_gemma":[0.9932319,0.00004037756,0.0001911906,0.0006255979,0.0002810717,0.0005014453,0.00003415842,0.00005864387,0.005035647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03202342,"threshold_uncertainty_score":0.9999719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02486123472222202,"score_gpt":0.2680445943309308,"score_spread":0.2431833596087088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}