{"id":"W2979703119","doi":"10.1371/journal.pgen.1008412","title":"Centromeric SMC1 promotes centromere clustering and stabilizes meiotic homolog pairing","year":2019,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Fonds de Recherche du Québec - Santé; National Institute of General Medical Sciences; Directorate for Biological Sciences; Agence Nationale de la Recherche; Fondation Bettencourt Schueller; Centre National de la Recherche Scientifique; Fondation pour la Recherche Médicale; National Institute of Environmental Health Sciences; Institut National de la Santé et de la Recherche Médicale; Fonds de Recherche du Québec-Société et Culture; National Science Foundation","keywords":"Synapsis; Meiosis; Homologous chromosome; Biology; Centromere; Genetics; Chromosomal crossover; Synaptonemal complex; Chromosome segregation; Bivalent (engine); Pairing; Chromosome; Gene; Chemistry; Physics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001011892,0.0002268218,0.0002240335,0.00004536684,0.00005945204,0.0000431635,0.0001956675,0.0001462111,0.00006897462],"category_scores_gemma":[0.00005329842,0.0002271263,0.00006689894,0.00007725982,0.00006079325,0.000004281047,0.0003547535,0.00009935888,0.00003961141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002042351,"about_ca_system_score_gemma":0.00004058938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002396047,"about_ca_topic_score_gemma":0.00001048324,"domain_scores_codex":[0.9985982,0.0000678263,0.0002209959,0.0005112878,0.0001754985,0.0004261671],"domain_scores_gemma":[0.9992135,0.00001847795,0.00008448258,0.000497587,0.00005716489,0.0001288596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002459557,0.00007867573,0.01544374,0.000137358,0.00008002342,0.00000390229,0.00008754702,0.0001192975,0.9817714,0.00001981557,0.00002680846,0.00220683],"study_design_scores_gemma":[0.0007595233,0.0007112494,0.002893387,0.0000471603,0.00006113704,0.00004131745,0.0001797433,0.008543816,0.9837724,0.0001210852,0.00245837,0.0004108285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961741,0.002290977,0.0002828866,0.00006601484,0.0002148107,0.0004790642,0.00001213182,0.0000472769,0.0004327204],"genre_scores_gemma":[0.994468,0.0003666666,0.004461345,0.00009654948,0.000116038,0.00001655312,0.00003259914,0.00005657772,0.0003856711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01255035,"threshold_uncertainty_score":0.9261941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009033265404438226,"score_gpt":0.2072336961619567,"score_spread":0.1982004307575184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}