{"id":"W2979710977","doi":"10.1016/j.jcmgh.2019.10.002","title":"RIPK1 Mediates TNF-Induced Intestinal Crypt Apoptosis During Chronic NF-κB Activation","year":2019,"lang":"en","type":"article","venue":"Cellular and Molecular Gastroenterology and Hepatology","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; Deutsche Krebshilfe; Genentech; National Cancer Institute; National Institutes of Health; GlaxoSmithKline; Deutsche Forschungsgemeinschaft; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; European Commission; Canadian Institutes of Health Research; American Cancer Society","keywords":"RIPK1; Tumor necrosis factor alpha; Apoptosis; Programmed cell death; Kinase; Chemistry; IκB kinase; Cancer research; Cell biology; Biology; Molecular biology; NF-κB; Immunology; Necroptosis; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002829695,0.0005166762,0.0002971159,0.0001692896,0.00022214,0.000370031,0.000324797,0.0003508661,0.002756128],"category_scores_gemma":[0.0001858706,0.0001364586,0.0004379446,0.0001170714,0.0003117343,0.0004375982,0.0002477898,0.000936845,0.00124335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004376876,"about_ca_system_score_gemma":0.000235295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001152791,"about_ca_topic_score_gemma":0.000125564,"domain_scores_codex":[0.9998516,0.0000213581,0.00001639517,0.00003088366,0.00002478753,0.00005486278],"domain_scores_gemma":[0.999801,0.00001938633,0.00008658968,0.0000228035,0.0000233881,0.00004682398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009460461,0.00007686318,0.0004503361,0.0002733026,0.0000149055,0.0001582304,0.00002223676,0.00008433979,0.9963432,0.0001568175,0.0001259025,0.00134787],"study_design_scores_gemma":[0.000168197,0.0007738954,0.01505897,0.00005500477,0.00005971583,0.001791207,0.0000669416,0.001266524,0.9757304,0.0002916052,0.004724415,0.00001323544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748908,0.01564864,0.005992005,0.0003395622,0.00009982265,0.00006540003,0.0007779703,0.0001625604,0.002023168],"genre_scores_gemma":[0.9928629,0.002898749,0.001767955,0.00007233935,0.00003155303,0.00007191741,0.0008191168,0.00001966083,0.001455819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002756128,"threshold_uncertainty_score":0.009220123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005654707051150907,"score_gpt":0.2023565891353889,"score_spread":0.196701882084238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}