{"id":"W2979717085","doi":"10.1021/acschemneuro.9b00476","title":"Interaction between Copper Chaperone Atox1 and Parkinson’s Disease Protein α-Synuclein Includes Metal-Binding Sites and Occurs in Living Cells","year":2019,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fondation Chalmers; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse","keywords":"Chaperone (clinical); Chemistry; Alpha-synuclein; Amyloid (mycology); Cell biology; Biochemistry; In vitro; Biophysics; Cytoplasm; In vivo; Plasma protein binding; Proximity ligation assay; Protein aggregation; Biology; Parkinson's disease; Receptor; Genetics; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001438738,0.000202743,0.0002163181,0.0001320485,0.0003090429,0.0002533797,0.000162555,0.0002279261,0.00060212],"category_scores_gemma":[0.0001396682,0.0001173062,0.0001672501,0.0001759615,0.0002165197,0.0001671841,0.0002387289,0.000256944,0.0002157506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002811015,"about_ca_system_score_gemma":0.0001487159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006930801,"about_ca_topic_score_gemma":0.0009611346,"domain_scores_codex":[0.9998189,0.00002579193,0.000005976442,0.0000620952,0.00006248787,0.00002482551],"domain_scores_gemma":[0.9999294,0.0000109166,0.00002084754,0.000006229374,0.00001275866,0.00001976951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006109674,0.000009968747,0.0004815995,0.00002161483,0.000007566673,0.00005285203,0.00002744918,0.00004278472,0.9986015,0.00006081369,0.00003890959,0.0005938045],"study_design_scores_gemma":[0.00001581524,0.0001890884,0.01302464,0.000008955012,0.00002208262,0.0005268456,0.00007154665,0.00179039,0.981076,0.0001519302,0.003115067,0.000007673337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949751,0.001643469,0.002409198,0.00007507714,0.00001747604,0.000005300177,0.00004709027,0.00003718715,0.0007901716],"genre_scores_gemma":[0.9964514,0.0004626676,0.001718881,0.00003483372,0.00000889783,0.000007716631,0.0001045478,0.000009577418,0.001201376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006930801,"threshold_uncertainty_score":0.002039492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03351428871523006,"score_gpt":0.3040101664697369,"score_spread":0.2704958777545068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}