{"id":"W2979717085","doi":"10.1021/acschemneuro.9b00476","title":"Interaction between Copper Chaperone Atox1 and Parkinson’s Disease Protein α-Synuclein Includes Metal-Binding Sites and Occurs in Living Cells","year":2019,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fondation Chalmers; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse","keywords":"Chaperone (clinical); Chemistry; Alpha-synuclein; Amyloid (mycology); Cell biology; Biochemistry; In vitro; Biophysics; Cytoplasm; In vivo; Plasma protein binding; Proximity ligation assay; Protein aggregation; Biology; Parkinson's disease; Receptor; Genetics; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000147552,0.0001590134,0.0002333754,0.0001128413,0.00007377558,0.00006527513,0.00009663665,0.00004364725,0.00001890225],"category_scores_gemma":[0.0003080228,0.0001317495,0.00003162462,0.0002352654,0.0002242555,0.0003808106,0.0002673324,0.0002152671,0.0000247953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005561554,"about_ca_system_score_gemma":0.00005410387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001832454,"about_ca_topic_score_gemma":8.677195e-7,"domain_scores_codex":[0.9985301,0.00004704637,0.0001721698,0.0005397931,0.0003516251,0.0003592776],"domain_scores_gemma":[0.9990752,0.0001723766,0.00005007027,0.0001865075,0.00002239547,0.0004934497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006641368,0.000122315,0.3709587,0.00005547851,0.00002047412,0.0000364178,0.00005064966,1.928488e-7,0.6283717,0.000004600169,0.000008699859,0.0003044097],"study_design_scores_gemma":[0.001231304,0.0002982417,0.5201374,0.0004980977,0.0001358203,0.00001723128,0.0000991549,0.0007241102,0.4762937,0.00005258909,0.0002340739,0.0002783108],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985669,0.0004007348,8.846339e-7,0.0003190152,0.00002893878,0.0005736967,0.00001775408,0.00002858621,0.00006347805],"genre_scores_gemma":[0.99958,0.00009247592,0.00006234676,0.000142478,0.00002907257,0.00003172818,0.000008278471,0.00001505838,0.0000385823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.152078,"threshold_uncertainty_score":0.5372589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03351428871523006,"score_gpt":0.3040101664697369,"score_spread":0.2704958777545068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}