{"id":"W2979725095","doi":"10.1182/blood.v120.21.2973.2973","title":"Phase 1b/2a Open-Label, Multiple-Dose, Dose-Escalation Study to Evaluate the Safety and Tolerability of SNS01-T Administered by Intravenous Infusion in Patients with Relapsed or Refractory Multiple Myeloma.","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Medicine; Tolerability; Multiple myeloma; In vivo; Apoptosis; Pharmacokinetics; Internal medicine; Pharmacology; Cancer research; Adverse effect; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009491552,0.001472494,0.002103466,0.0003755139,0.0003848928,0.0009004553,0.0006782199,0.001208139,0.005308941],"category_scores_gemma":[0.0004997746,0.0005516231,0.001091471,0.0003883598,0.0006894154,0.0008024785,0.0002567561,0.002777452,0.001021366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001050728,"about_ca_system_score_gemma":0.001420488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008977349,"about_ca_topic_score_gemma":0.002143839,"domain_scores_codex":[0.9997628,0.00008822016,0.000009018137,0.00005382103,0.00003147078,0.00005456801],"domain_scores_gemma":[0.9996605,0.00003397363,0.00007437592,0.0000365131,0.00002785317,0.0001668144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5870875,0.1239948,0.003494778,0.001242652,0.001600451,0.0003182538,0.00032966,0.00478051,0.1347037,0.00073377,0.008025459,0.1336886],"study_design_scores_gemma":[0.3016437,0.6702654,0.007012832,0.00005015021,0.0003860903,0.0003139124,0.00006208862,0.003098055,0.01023197,0.0003953983,0.006498498,0.00004174126],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870974,0.002439144,0.001832069,0.0004668555,0.0002343331,0.003818715,0.001564186,0.0002081044,0.002339185],"genre_scores_gemma":[0.9774002,0.002000015,0.004531504,0.0009793993,0.0001611388,0.00523456,0.00262616,0.00009201362,0.006974966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005308941,"threshold_uncertainty_score":0.0177601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02299840380290632,"score_gpt":0.3060890977822555,"score_spread":0.2830906939793492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}