{"id":"W2979725095","doi":"10.1182/blood.v120.21.2973.2973","title":"Phase 1b/2a Open-Label, Multiple-Dose, Dose-Escalation Study to Evaluate the Safety and Tolerability of SNS01-T Administered by Intravenous Infusion in Patients with Relapsed or Refractory Multiple Myeloma.","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Medicine; Tolerability; Multiple myeloma; In vivo; Apoptosis; Pharmacokinetics; Internal medicine; Pharmacology; Cancer research; Adverse effect; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005053525,0.0001714512,0.0002441006,0.00003242033,0.000113402,0.00002062321,0.0002438586,0.00007182253,0.000006495185],"category_scores_gemma":[0.0002755758,0.0001117786,0.00001512331,0.0001681117,0.00006370047,0.00001953256,0.0002578124,0.00009239023,0.000002098391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000101363,"about_ca_system_score_gemma":0.00005478384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008785104,"about_ca_topic_score_gemma":0.0002375136,"domain_scores_codex":[0.9986605,0.0002075066,0.0003973597,0.0003326228,0.0001732159,0.0002287875],"domain_scores_gemma":[0.9990355,0.00006166681,0.0001395008,0.0005454053,0.00009895524,0.0001190212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007649968,0.0611646,0.5531877,0.00002670996,0.0001098192,4.49347e-7,0.001624732,0.000003841905,0.3413104,0.000004307934,0.0001212282,0.0347962],"study_design_scores_gemma":[0.05114903,0.005057877,0.9045455,0.00001790215,0.000118702,0.000001368423,0.0002338288,0.0000431567,0.03583364,0.000002134867,0.002760203,0.0002366369],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972326,0.0001763196,0.00008779777,0.00004495669,0.0000385177,0.002123639,0.0002462988,0.00000633526,0.0000435556],"genre_scores_gemma":[0.9989101,0.00002484541,0.0004296241,0.00007350593,0.00003587619,0.0001309777,0.0003309968,0.00001627406,0.00004785291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3513578,"threshold_uncertainty_score":0.4558199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02299840380290632,"score_gpt":0.3060890977822555,"score_spread":0.2830906939793492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}