{"id":"W2979748361","doi":"10.1182/blood.v126.23.825.825","title":"Phase 1b/2 Study of the Efficacy and Safety of Sonidegib (LDE225) in Combination with Ruxolitinib (INC424) in Patients with Myelofibrosis","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Ruxolitinib; Medicine; Myelofibrosis; Internal medicine; Phases of clinical research; Janus kinase inhibitor; Oncology; Gastroenterology; Surgery; Bone marrow; Toxicity; Janus kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001597728,0.001494055,0.00178248,0.0005186744,0.0003847688,0.001087893,0.0006365639,0.001194475,0.004984686],"category_scores_gemma":[0.000823669,0.0006168073,0.001303002,0.0003627706,0.0006789723,0.0008918836,0.0004201564,0.003158974,0.001325784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001059829,"about_ca_system_score_gemma":0.001284333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006785102,"about_ca_topic_score_gemma":0.00155358,"domain_scores_codex":[0.9995509,0.0002044898,0.0000238603,0.0001004754,0.00005099157,0.00006926103],"domain_scores_gemma":[0.9995503,0.0000516744,0.00007647761,0.00003757296,0.00004291384,0.0002409999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6148121,0.1478822,0.01309382,0.001053366,0.001733978,0.00063451,0.0003864544,0.003106607,0.08311404,0.0004086056,0.008079794,0.1256944],"study_design_scores_gemma":[0.4329436,0.5309536,0.01939073,0.00005320519,0.0006085871,0.0008174013,0.00008131484,0.001918193,0.008248952,0.0002642324,0.004670636,0.00004948814],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911877,0.001492497,0.0005662201,0.0004902241,0.00007498433,0.002361831,0.001855788,0.00009241034,0.001878296],"genre_scores_gemma":[0.9870269,0.0009888634,0.001810666,0.0008710593,0.000112054,0.002608065,0.003751898,0.00002935485,0.002801301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004984686,"threshold_uncertainty_score":0.01667541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01599363949920804,"score_gpt":0.2636582206812186,"score_spread":0.2476645811820106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}