{"id":"W2979790944","doi":"10.1172/jci.insight.131597","title":"Transcriptional regulatory model of fibrosis progression in the human lung","year":2019,"lang":"en","type":"article","venue":"JCI Insight","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"U.S. National Library of Medicine; National Human Genome Research Institute; National Institutes of Health; National Heart, Lung, and Blood Institute; KU Leuven; National Center for Advancing Translational Sciences; Fonds Wetenschappelijk Onderzoek; National Institute of Allergy and Infectious Diseases; European Respiratory Society","keywords":"Fibrosis; Bleomycin; microRNA; Idiopathic pulmonary fibrosis; Pulmonary fibrosis; Lung; Gene expression; Knockout mouse; Gene; Biology; Pathology; Regulation of gene expression; Cancer research; Medicine; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006841681,0.0004232829,0.0003783487,0.0004187214,0.0001911894,0.0004914068,0.0004346798,0.0003210106,0.001862648],"category_scores_gemma":[0.0007241484,0.0002146397,0.0007029411,0.000237082,0.0005305768,0.0003066775,0.0002248878,0.0004872128,0.000349414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008039533,"about_ca_system_score_gemma":0.0006119807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00250914,"about_ca_topic_score_gemma":0.002033957,"domain_scores_codex":[0.999592,0.000137687,0.00001192414,0.0001530288,0.00006407791,0.00004120934],"domain_scores_gemma":[0.9997476,0.0001427575,0.00005101163,0.00002138029,0.0000241354,0.00001306254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00058042,0.0003126635,0.007221165,0.000208165,0.0001367244,0.0004492463,0.0003261994,0.5847073,0.26937,0.1160973,0.0008592466,0.01973153],"study_design_scores_gemma":[0.00008126478,0.0002833624,0.003144723,0.000008407912,0.00004428549,0.0001738553,0.00004380951,0.954064,0.01333143,0.02599156,0.002812897,0.00002032067],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3393525,0.0007436631,0.6481569,0.001015774,0.00006896778,0.0001723347,0.001388395,0.0007555694,0.008345734],"genre_scores_gemma":[0.9383387,0.0004097244,0.05490322,0.0002103606,0.00003443977,0.000415077,0.0005612025,0.00003835049,0.005088937],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00250914,"threshold_uncertainty_score":0.006231189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01654732041955749,"score_gpt":0.2808661872402134,"score_spread":0.264318866820656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}