{"id":"W2979792224","doi":"10.1016/j.envres.2019.108807","title":"Serotonin and 5-HT3 receptors sensitize human skin cells to direct irradiation cell death but not to soluble radiation-induced bystander signals","year":2019,"lang":"en","type":"article","venue":"Environmental Research","topic":"Effects of Radiation Exposure","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"CANDU Owners Group; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Bruce Power","keywords":"Bystander effect; HaCaT; Receptor; Serotonin; Ketanserin; Programmed cell death; Ondansetron; Chemistry; Cell type; Cell; Pharmacology; Irradiation; 5-HT receptor; Ionizing radiation; Toxicology; Cancer research; Cell biology; Biology; Immunology; Internal medicine; Medicine; Apoptosis; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001471285,0.0002457868,0.0003619046,0.0004417715,0.00025662,0.00008429107,0.0001437612,0.0001838734,0.001332211],"category_scores_gemma":[0.0001115911,0.0002512861,0.00007260451,0.0002810417,0.00004697084,0.0001765643,0.0001622559,0.0004447106,0.00270636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008042974,"about_ca_system_score_gemma":0.00007643466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002228961,"about_ca_topic_score_gemma":0.00001401971,"domain_scores_codex":[0.9965972,0.0003953637,0.0003234494,0.0007108209,0.001314099,0.0006590572],"domain_scores_gemma":[0.9982253,0.000484551,0.00006687893,0.0005115145,0.00003341387,0.0006782957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001590317,0.0001717229,0.0271867,0.00005606336,0.00003221391,0.00001360278,0.001267161,0.0002605731,0.9639759,0.00001021623,0.003233342,0.003633492],"study_design_scores_gemma":[0.001749346,0.001710322,0.1900601,0.00004533193,0.00001863381,0.00000574505,0.0006009514,0.0003699547,0.7997162,0.00001641336,0.005428137,0.0002788521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917238,0.00006752978,0.00001264821,0.0009822557,0.0001824398,0.003135019,0.0000289759,0.00004553462,0.003821794],"genre_scores_gemma":[0.9811222,0.00004596737,0.0004706327,0.0006743262,0.0001900793,0.0001067569,0.00008684929,0.000073649,0.01722956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1642597,"threshold_uncertainty_score":0.9999939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02584235428879405,"score_gpt":0.324606459561222,"score_spread":0.298764105272428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}