{"id":"W2979816540","doi":"10.1182/blood.v118.21.167.167","title":"B-Cell Depletion, Remissions of Malignancy, and Cytokine-Associated Toxicity in a Clinical Trial of T Cells Genetically-Engineered to Express An Anti-CD19 Chimeric Antigen Receptor","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Chimeric antigen receptor; Adoptive cell transfer; CD19; Immunology; Fludarabine; Chronic lymphocytic leukemia; Lymphoma; Antigen; Leukemia; Cyclophosphamide; T cell; Cancer research; Internal medicine; Chemotherapy; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001567574,0.001130537,0.001501641,0.0004102908,0.0005251241,0.0008481147,0.0006647051,0.001532131,0.001548266],"category_scores_gemma":[0.001045672,0.0003372573,0.00058893,0.0002780389,0.0009089153,0.0005605192,0.0003149645,0.002518119,0.0004488773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000663397,"about_ca_system_score_gemma":0.001007203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005433782,"about_ca_topic_score_gemma":0.0009287099,"domain_scores_codex":[0.9994203,0.0003107372,0.00003011089,0.00005008582,0.00005344808,0.0001353131],"domain_scores_gemma":[0.9992777,0.0002153969,0.00008282137,0.0000567575,0.00004009217,0.0003272239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6169543,0.09221727,0.009163387,0.001055342,0.00102385,0.002395774,0.0006419443,0.005581595,0.08028995,0.002048963,0.006680517,0.1819471],"study_design_scores_gemma":[0.2719093,0.7020459,0.00763339,0.00005460811,0.0001716811,0.0009737273,0.00005831009,0.002494916,0.01000927,0.0002901098,0.004323808,0.00003490971],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947654,0.001240194,0.0005136795,0.0003971613,0.0001272395,0.0007681531,0.0001661718,0.00005937975,0.001962528],"genre_scores_gemma":[0.9950597,0.0006541415,0.0005916121,0.0005431999,0.0001130522,0.001122488,0.000495974,0.000015898,0.001403882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001567574,"threshold_uncertainty_score":0.008290231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05633769417147613,"score_gpt":0.326840488072401,"score_spread":0.2705027939009249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}