{"id":"W2979840360","doi":"10.1158/0008-5472.can-19-1840","title":"Association of Genomic Domains in <i>BRCA1</i> and <i>BRCA2</i> with Prostate Cancer Risk and Aggressiveness","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Centre hospitalier universitaire de Québec; Amgen (Canada); Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Jonsson Comprehensive Cancer Center; National Center for Advancing Translational Sciences; European Regional Development Fund; Canadian Institutes of Health Research; lékařská fakulta Univerzity Karlovy; University of California, San Francisco; National Institutes of Health; Kerry Group Kuok Foundation; Freistaat Sachsen; Centro de Investigación Biomédica en Red de Cáncer; Fox Chase Cancer Center; Ministero dello Sviluppo Economico; Fondazione Italiana per la Ricerca sul Cancro; Medical Research Council; Uppsala Universitet; National Institute of General Medical Sciences; Institut National Du Cancer; Aalborg Universitetshospital; Deutsche Krebshilfe; Sahlgrenska Universitetssjukhuset; Associazione Italiana per la Ricerca sul Cancro; KWF Kankerbestrijding; Lietuvos Mokslo Taryba; Ovarian Cancer Research Fund; Ministerio de Economía y Competitividad; Landspítali Háskólasjúkrahús; Cancer Association of South Africa; Karolinska Institutet; Linköpings Universitet; Hungarian Scientific Research Fund; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministero della Salute; Generalitat de Catalunya; Seoul National University; National Breast Cancer Foundation; European Commission; National Institute for Health and Care Research; U.S. Department of Defense; Cancer Research UK; Government of Canada; National Cancer Institute; Liga Portuguesa Contra o Cancro; Hospital de Câncer de Barretos; Israel Cancer Association; Institut Català de la Salut; University of Pennsylvania; Fundación Mutua Madrileña; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Aalborg Universitet; Genome Canada; Breast Cancer Research Foundation; McGill University; Univerzita Karlova v Praze; Clalit Health Services; Deutsches Krebsforschungszentrum; American Cancer Society; Fonds Wetenschappelijk Onderzoek; Cancer Center, University of Kansas; Cancerfonden; NRG Oncology; Fondation du cancer du sein du Québec; Memorial Sloan-Kettering Cancer Center; QIMR Berghofer Medical Research Institute; Ministério da Ciência, Tecnologia e Inovação; Dr. Ralph and Marian Falk Medical Research Trust; European Social Fund; University of Chicago; Cancer Research Institute; Kansas Bioscience Authority; Instituto de Salud Carlos III; Ohio State University; National Health and Medical Research Council; Jewish General Hospital; Fisher Center for Alzheimer's Research Foundation; Cancer Australia; Georgetown University; College of Medicine, Seoul National University; Susan G. Komen for the Cure; Beth Israel Deaconess Medical Center; Istituto Oncologico Veneto; Umeå Universitet; Royal Marsden NHS Foundation Trust","keywords":"Prostate cancer; Cancer; Oncology; Medicine; BRCA2 Protein; Gynecology; Prostate; Internal medicine; Biology; Genetics; Gene; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006259448,0.0001027289,0.0001586307,0.00009618052,0.00006389849,0.00002596408,0.0001161507,0.0001109775,0.00003261475],"category_scores_gemma":[0.00004334365,0.0000917975,0.00001593976,0.0002121679,0.0001560646,0.000008578255,0.0001324421,0.0002141565,0.000002239615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003205539,"about_ca_system_score_gemma":0.0005405247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009853061,"about_ca_topic_score_gemma":0.002792311,"domain_scores_codex":[0.9987237,0.000166061,0.0001543441,0.0003916743,0.0002598464,0.0003043375],"domain_scores_gemma":[0.9992831,0.00005234766,0.0001306045,0.0002292661,0.0002480208,0.00005665005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003809901,0.00001717853,0.5954096,0.00009222787,0.00007599896,0.000001326164,0.0004428774,0.0005512593,0.3977412,0.000008175281,0.0005939188,0.004685312],"study_design_scores_gemma":[0.005085959,0.0005341777,0.5062172,0.0003078693,0.00004471847,0.000006249046,0.0006991747,0.0000984705,0.4469003,0.0002344139,0.03947552,0.0003959733],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859795,0.01279139,0.000008646346,0.0003386042,0.00007034364,0.0004892237,0.0001308256,0.000003112507,0.0001883258],"genre_scores_gemma":[0.9816511,0.01659431,0.00009804361,0.00005274497,0.00007633368,0.0002686792,0.00001388869,0.00002529159,0.001219577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08919241,"threshold_uncertainty_score":0.3743393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01150623735364341,"score_gpt":0.3197608896350697,"score_spread":0.3082546522814263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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