{"id":"W2979840360","doi":"10.1158/0008-5472.can-19-1840","title":"Association of Genomic Domains in <i>BRCA1</i> and <i>BRCA2</i> with Prostate Cancer Risk and Aggressiveness","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Centre hospitalier universitaire de Québec; Amgen (Canada); Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Jonsson Comprehensive Cancer Center; National Center for Advancing Translational Sciences; European Regional Development Fund; Canadian Institutes of Health Research; lékařská fakulta Univerzity Karlovy; University of California, San Francisco; National Institutes of Health; Kerry Group Kuok Foundation; Freistaat Sachsen; Centro de Investigación Biomédica en Red de Cáncer; Fox Chase Cancer Center; Ministero dello Sviluppo Economico; Fondazione Italiana per la Ricerca sul Cancro; Medical Research Council; Uppsala Universitet; National Institute of General Medical Sciences; Institut National Du Cancer; Aalborg Universitetshospital; Deutsche Krebshilfe; Sahlgrenska Universitetssjukhuset; Associazione Italiana per la Ricerca sul Cancro; KWF Kankerbestrijding; Lietuvos Mokslo Taryba; Ovarian Cancer Research Fund; Ministerio de Economía y Competitividad; Landspítali Háskólasjúkrahús; Cancer Association of South Africa; Karolinska Institutet; Linköpings Universitet; Hungarian Scientific Research Fund; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministero della Salute; Generalitat de Catalunya; Seoul National University; National Breast Cancer Foundation; European Commission; National Institute for Health and Care Research; U.S. Department of Defense; Cancer Research UK; Government of Canada; National Cancer Institute; Liga Portuguesa Contra o Cancro; Hospital de Câncer de Barretos; Israel Cancer Association; Institut Català de la Salut; University of Pennsylvania; Fundación Mutua Madrileña; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Aalborg Universitet; Genome Canada; Breast Cancer Research Foundation; McGill University; Univerzita Karlova v Praze; Clalit Health Services; Deutsches Krebsforschungszentrum; American Cancer Society; Fonds Wetenschappelijk Onderzoek; Cancer Center, University of Kansas; Cancerfonden; NRG Oncology; Fondation du cancer du sein du Québec; Memorial Sloan-Kettering Cancer Center; QIMR Berghofer Medical Research Institute; Ministério da Ciência, Tecnologia e Inovação; Dr. Ralph and Marian Falk Medical Research Trust; European Social Fund; University of Chicago; Cancer Research Institute; Kansas Bioscience Authority; Instituto de Salud Carlos III; Ohio State University; National Health and Medical Research Council; Jewish General Hospital; Fisher Center for Alzheimer's Research Foundation; Cancer Australia; Georgetown University; College of Medicine, Seoul National University; Susan G. Komen for the Cure; Beth Israel Deaconess Medical Center; Istituto Oncologico Veneto; Umeå Universitet; Royal Marsden NHS Foundation Trust","keywords":"Prostate cancer; Cancer; Oncology; Medicine; BRCA2 Protein; Gynecology; Prostate; Internal medicine; Biology; Genetics; Gene; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003187633,0.000239469,0.0001787535,0.0007017265,0.0002663811,0.0003874057,0.0002148882,0.0003220522,0.003299599],"category_scores_gemma":[0.0009717066,0.0001081376,0.0004794142,0.000673077,0.0002506824,0.0001217341,0.000261705,0.0004788796,0.000212708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001644879,"about_ca_system_score_gemma":0.000153692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005448156,"about_ca_topic_score_gemma":0.004458056,"domain_scores_codex":[0.9997393,0.00006059019,0.00002080957,0.00008189382,0.00005067833,0.00004665008],"domain_scores_gemma":[0.9988439,0.0002326076,0.0005916703,0.00004784422,0.00007656575,0.0002073584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007946598,0.00005368001,0.987485,0.00001458974,0.0002697292,0.0002178488,0.00005511202,0.0001864649,0.008249124,0.00006784593,0.0002190417,0.002386805],"study_design_scores_gemma":[0.00001296576,0.00009626717,0.9973423,0.000006232615,0.00008048934,0.0006442252,0.00006892462,0.0004147179,0.0009662571,0.00007279202,0.0002893906,0.000005430349],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989209,0.0001903397,0.0001704566,0.00002842222,0.000005920128,0.000003635356,0.0003268339,0.00000513851,0.0003483306],"genre_scores_gemma":[0.9993284,0.00002934908,0.0001222393,0.00001761965,0.000006063345,0.000002026302,0.0002812546,0.000002752671,0.0002104089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005448156,"threshold_uncertainty_score":0.01103824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01150623735364341,"score_gpt":0.3197608896350697,"score_spread":0.3082546522814263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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