{"id":"W2979853677","doi":"10.1182/blood.v124.21.467.467","title":"Platelet Desialylation: A Novel Mechanism of Fc-Independent Platelet Clearance and a Potential Diagnostic Biomarker and Therapeutic Target in immune Thrombocytopenia","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of Toronto; St. Michael's Hospital","funders":"","keywords":"Platelet; Antibody; Flow cytometry; Monoclonal antibody; Chemistry; Autoantibody; Immunology; Platelet activation; Spleen; Immune system; Platelet Glycoprotein GPIb-IX Complex; Platelet membrane glycoprotein; Western blot; Neuraminidase; Isoantibodies; Immunofluorescence; Biology; Biochemistry; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003289203,0.0004677289,0.0002278757,0.0002680242,0.0000898639,0.000380063,0.0003078079,0.000432522,0.0007008594],"category_scores_gemma":[0.0001937419,0.000144234,0.0002844482,0.0001559645,0.0002459044,0.0003383142,0.0001911778,0.0006052441,0.0002002236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003108875,"about_ca_system_score_gemma":0.0001188807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001915003,"about_ca_topic_score_gemma":0.0001551046,"domain_scores_codex":[0.999874,0.00003513558,0.00001004197,0.0000275124,0.00003090021,0.00002242492],"domain_scores_gemma":[0.9998907,0.00001806514,0.00004498958,0.00001569975,0.00001721832,0.00001341234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004349488,0.00004907938,0.002696754,0.00009775019,0.00002909588,0.0002982172,0.00002201408,0.0001463952,0.9859386,0.0004864309,0.0000956132,0.009705029],"study_design_scores_gemma":[0.0000755718,0.001374518,0.02275486,0.00002535765,0.000112878,0.004777948,0.00002868024,0.004745748,0.960661,0.0005407514,0.004890717,0.00001195043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9633934,0.01608142,0.01724109,0.0003886989,0.00003469178,0.00008837684,0.0001567767,0.0001131478,0.002502445],"genre_scores_gemma":[0.9938896,0.002099418,0.002844839,0.0001184716,0.00002894502,0.0000211178,0.0001410147,0.000006492931,0.0008502001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007008594,"threshold_uncertainty_score":0.002344608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01188502320059135,"score_gpt":0.2349424319804738,"score_spread":0.2230574087798825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}