{"id":"W2979861224","doi":"10.1182/blood.v104.11.3364.3364","title":"Depletion of the Intracellular Akt Kinase, and Its Downstream Signaling, Mediates Synergy between the Proteasome Inhibitor MG-132 and the Heat Shock Protein 90 Inhibitor 17-AAG in the Multiple Myeloma Cell Line U266.","year":2004,"lang":"en","type":"article","venue":"Blood","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Protein kinase B; Geldanamycin; Proteasome inhibitor; Heat shock protein; Hsp90 inhibitor; Apoptosis; Proteasome; Kinase; Annexin A5; Annexin; Chemistry; Inhibitor of apoptosis; Molecular biology; Bortezomib; Hsp90; Biology; Programmed cell death; Biochemistry; Immunology; Multiple myeloma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002500291,0.0006252722,0.0005008634,0.0003891404,0.0001784923,0.0002625513,0.0002899852,0.0003014357,0.001433708],"category_scores_gemma":[0.0001134976,0.0002197161,0.000406558,0.0004043843,0.0002387399,0.0002024857,0.0001907129,0.0007469318,0.00062119],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003545864,"about_ca_system_score_gemma":0.0003726023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009031727,"about_ca_topic_score_gemma":0.001780342,"domain_scores_codex":[0.9996983,0.00007470104,0.00003288484,0.00003788944,0.00009196642,0.00006425228],"domain_scores_gemma":[0.9998789,0.00002040533,0.0000263573,0.00001600076,0.00001037333,0.0000480072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006578414,0.0002485547,0.0001783291,0.00007610711,0.00001672609,0.00007442872,0.00001924265,0.000265047,0.9960957,0.0001247027,0.0001964222,0.00204688],"study_design_scores_gemma":[0.00008806378,0.001814417,0.003166359,0.000009329893,0.00002368056,0.0001881202,0.00001993597,0.001603508,0.9912607,0.00003527824,0.00178471,0.000006006805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916577,0.002942145,0.001275996,0.000171166,0.00008536157,0.00006725932,0.0007592784,0.0001500679,0.002891057],"genre_scores_gemma":[0.9927659,0.001389444,0.002169773,0.00006181483,0.00002407153,0.00008359575,0.0008477484,0.00001836502,0.002639371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001433708,"threshold_uncertainty_score":0.004796207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007654562299387021,"score_gpt":0.1978189796808078,"score_spread":0.1901644173814208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}