{"id":"W2979918361","doi":"10.1097/01.cot.0000603992.76162.8f","title":"New Guidelines for Assessing BRCA1/2-Related Cancers","year":2019,"lang":"en","type":"article","venue":"Oncology Times","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Genetic counseling; Medicine; Genetic testing; Breast cancer; Family history; Ovarian cancer; Gynecology; Population; Family medicine; BRCA mutation; Cancer; Risk assessment; Oncology; Internal medicine; Genetics; Environmental health; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000182587,0.0001189743,0.0001643113,0.0000372865,0.00005812429,0.00001890524,0.0001730671,0.0002558084,0.0005528298],"category_scores_gemma":[0.000144392,0.0001165939,0.00008182206,0.00007594068,0.00004318594,0.000005627848,0.00005807086,0.00006436446,0.00008779858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001959511,"about_ca_system_score_gemma":0.001770052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007271867,"about_ca_topic_score_gemma":0.00007832862,"domain_scores_codex":[0.9991238,0.00003148925,0.0002370666,0.0003292227,0.00006324814,0.0002152311],"domain_scores_gemma":[0.9992967,0.00003611917,0.0001125131,0.0002701363,0.000226494,0.00005809525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005121532,0.00001412335,0.001338671,0.00001199968,0.000145866,9.165743e-7,0.00005798178,0.002405071,0.1737117,0.0003116708,0.7520691,0.06988165],"study_design_scores_gemma":[0.001233409,0.0002768578,0.0004455494,0.00001236804,0.00003925967,0.00001761046,0.0001492373,0.0006604196,0.03876114,0.000614656,0.9576035,0.0001859888],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6072559,0.01394243,0.03787326,0.02886755,0.00975051,0.002428961,0.00009522603,0.00018533,0.2996008],"genre_scores_gemma":[0.5130158,0.0003214034,0.2000364,0.006830281,0.001886767,0.0001787596,0.0005125217,0.0001207516,0.2770973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2055344,"threshold_uncertainty_score":0.6053099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03039297416131675,"score_gpt":0.3747976264222281,"score_spread":0.3444046522609114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}