{"id":"W2979923058","doi":"10.1182/blood.v108.11.3530.3530","title":"Preliminary Safety and Efficacy Results from an International Phase 3b Study for Expanded Access to Bortezomib in 624 Patients with Relapsed and/or Refractory Multiple Myeloma.","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Bortezomib; Medicine; Multiple myeloma; Progressive disease; Adverse effect; Internal medicine; Proteasome inhibitor; Dexamethasone; Refractory (planetary science); Gastroenterology; Phases of clinical research; Surgery; Urology; Toxicity; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003844041,0.001153561,0.001491474,0.0003729351,0.0005892428,0.0009483281,0.0006077593,0.0008115759,0.004421257],"category_scores_gemma":[0.0022334,0.0004499579,0.001307447,0.0005680976,0.0006167252,0.0006136231,0.0005000517,0.00230824,0.001043069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008046182,"about_ca_system_score_gemma":0.001222184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009807434,"about_ca_topic_score_gemma":0.001906424,"domain_scores_codex":[0.9987364,0.0007516734,0.00008430616,0.0001636855,0.0001292101,0.0001346953],"domain_scores_gemma":[0.9980322,0.0004641527,0.000427389,0.0001914602,0.000155834,0.0007290736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6627918,0.05031446,0.04631858,0.0009131931,0.002312077,0.0005247794,0.0005170989,0.002664671,0.05130068,0.000204184,0.009756206,0.1723821],"study_design_scores_gemma":[0.3932644,0.407017,0.1785572,0.0001125315,0.001635056,0.0009617827,0.0001233011,0.00139475,0.005624691,0.0003416762,0.01090331,0.00006441247],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9793264,0.005031401,0.001777098,0.0007468579,0.00008533928,0.003229446,0.004268952,0.0001663531,0.005368113],"genre_scores_gemma":[0.9779109,0.001730604,0.002750176,0.001335745,0.0001838243,0.003240522,0.01064219,0.00008191614,0.002123995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004421257,"threshold_uncertainty_score":0.02032948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03056316464014592,"score_gpt":0.3498052333605649,"score_spread":0.319242068720419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}