{"id":"W2979938421","doi":"10.3389/fonc.2019.01036","title":"Hypoxia Can Induce Migration of Glioblastoma Cells Through a Methylation-Dependent Control of ODZ1 Gene Expression","year":2019,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Toronto Western Hospital; Princess Margaret Cancer Centre","funders":"Instituto de Salud Carlos III; Instituto de Investigación Marqués de Valdecilla; Brain Tumour Foundation of Canada","keywords":"Downregulation and upregulation; Methylation; Cancer research; CpG site; Biology; DNA methylation; Hypoxia (environmental); RHOA; Transactivation; SOX2; Regulation of gene expression; Cell biology; Gene expression; Molecular biology; Chemistry; Gene; Signal transduction; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00030503,0.0001278425,0.0003379847,0.0001065894,0.00001759144,0.000003223209,0.0001522697,0.000338672,0.00001652312],"category_scores_gemma":[0.00005700627,0.0001274634,0.00007478132,0.0001167249,0.00006388063,0.000006475067,0.00004939055,0.00009593652,0.000001607361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005472614,"about_ca_system_score_gemma":0.000148627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001111598,"about_ca_topic_score_gemma":0.0001816869,"domain_scores_codex":[0.9987249,0.0002167837,0.0004429674,0.0002893926,0.0001512683,0.0001747287],"domain_scores_gemma":[0.9991578,0.00003748394,0.0003496213,0.0002938215,0.0001254513,0.00003579915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003365396,0.000115515,0.02664264,0.00002184608,0.00003303241,9.908141e-7,0.0002901555,0.002006313,0.968087,0.00002265405,0.0002868226,0.002156485],"study_design_scores_gemma":[0.001617534,0.001050668,0.003637073,0.00001383204,0.00001893864,7.362614e-7,0.000189378,0.0003980995,0.9872835,0.0004585379,0.005213112,0.0001185375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.94803,0.001638897,0.04853699,0.00007810457,0.000738616,0.000367317,0.00003494131,0.000003460137,0.0005716682],"genre_scores_gemma":[0.9855233,0.000429186,0.01367801,0.00005725016,0.00006948636,0.00001964779,0.00004914414,0.0000159698,0.0001579833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03749331,"threshold_uncertainty_score":0.5197806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007265723459418414,"score_gpt":0.2515031897507613,"score_spread":0.2442374662913429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}