{"id":"W2979970416","doi":"10.1182/blood.v104.11.711.711","title":"Leukemic Stem Cells of Chronic Phase CML Patients Consistently Display Very High BCR-ABL Transcript Levels and Reduced Responsiveness to Imatinib Mesylate in Addition to Generating a Rare Subset That Produce Imatinib Mesylate-Resistant Differentiated Progeny.","year":2004,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"CD38; Imatinib mesylate; CD34; Haematopoiesis; Cancer research; Stem cell; Imatinib; Myeloid leukemia; Biology; Immunology; Medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009150081,0.0002096611,0.0001907329,0.0004855291,0.0001741052,0.0002144027,0.000075053,0.0001680554,0.004314102],"category_scores_gemma":[0.0001364436,0.00008678006,0.00009648072,0.0003059267,0.0001481783,0.0001051717,0.0001666982,0.0002113124,0.0005668784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009927648,"about_ca_system_score_gemma":0.00006934684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003420175,"about_ca_topic_score_gemma":0.0004236139,"domain_scores_codex":[0.9999287,0.000009916102,0.00001003721,0.0000143175,0.00002178855,0.00001523127],"domain_scores_gemma":[0.9999114,0.00002010585,0.00002020245,0.00001280519,0.00001085849,0.00002467295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003519651,0.00004883802,0.01753192,0.00003436201,0.00001429846,0.0002574704,0.0001217777,0.00006348309,0.9752645,0.0001227094,0.0001789854,0.006009799],"study_design_scores_gemma":[0.0002015436,0.002450699,0.4886715,0.00002769525,0.00008651946,0.01056255,0.0004699339,0.001041962,0.4819453,0.0003609569,0.01416411,0.0000172458],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973758,0.000330119,0.0004745547,0.00002789578,0.000003997614,0.00002558684,0.000659111,0.00002351302,0.001079375],"genre_scores_gemma":[0.9967354,0.0001653336,0.000578207,0.00002689803,0.000006104532,0.00005106979,0.001520953,0.00000708486,0.0009089734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004314102,"threshold_uncertainty_score":0.01443207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02283301946857158,"score_gpt":0.2615655358448558,"score_spread":0.2387325163762842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}