{"id":"W2979970416","doi":"10.1182/blood.v104.11.711.711","title":"Leukemic Stem Cells of Chronic Phase CML Patients Consistently Display Very High BCR-ABL Transcript Levels and Reduced Responsiveness to Imatinib Mesylate in Addition to Generating a Rare Subset That Produce Imatinib Mesylate-Resistant Differentiated Progeny.","year":2004,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"CD38; Imatinib mesylate; CD34; Haematopoiesis; Cancer research; Stem cell; Imatinib; Myeloid leukemia; Biology; Immunology; Medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003470714,0.0006307632,0.001133134,0.0004306033,0.0001526902,0.00005923677,0.000207039,0.0002107644,0.00007216336],"category_scores_gemma":[0.0001430818,0.0005708465,0.0001613592,0.0006512804,0.00009518125,0.0002235543,0.0001011314,0.0002943283,0.00001798525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001707231,"about_ca_system_score_gemma":0.00124938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002551248,"about_ca_topic_score_gemma":0.0001880276,"domain_scores_codex":[0.9959933,0.0002749952,0.00116689,0.001073944,0.000707667,0.0007832363],"domain_scores_gemma":[0.9979814,0.0001274259,0.0004127737,0.0007566478,0.0002992828,0.0004224153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003064028,0.003178637,0.001517358,0.001029698,0.0004431806,0.0002279163,0.002677571,0.0002543254,0.9847227,0.00002080363,0.00004979809,0.002814001],"study_design_scores_gemma":[0.04907032,0.00292545,0.04040042,0.002900337,0.0006799311,0.00005396882,0.0001935255,0.0001605572,0.9030368,0.00001981135,0.00003067061,0.0005282302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925429,0.0006129765,0.00005390629,0.0001748078,0.0002315206,0.004520926,0.001748434,0.00009637544,0.00001818445],"genre_scores_gemma":[0.9967201,0.00003093079,0.001565678,0.0001010835,0.000072433,0.0005296956,0.0007553729,0.0001092347,0.0001154319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08168591,"threshold_uncertainty_score":0.9996743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02283301946857158,"score_gpt":0.2615655358448558,"score_spread":0.2387325163762842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}