{"id":"W2979971137","doi":"10.1182/blood.v122.21.3678.3678","title":"Phosphatidylinositol-3-Kinase p110d Uniquely Promotes Gain-Of-Function PTPN11-Induced GM-CSF Hypersensitivity In a Model Of Juvenile Myelomonocytic Leukemia","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Discovery Centre; University Health Network; Ontario Institute for Cancer Research","funders":"","keywords":"Juvenile myelomonocytic leukemia; PTPN11; KRAS; Cancer research; Neuroblastoma RAS viral oncogene homolog; PI3K/AKT/mTOR pathway; MAPK/ERK pathway; Leukemia; Trametinib; Idelalisib; Biology; Immunology; PTEN; Medicine; Internal medicine; Kinase; Mutation; Haematopoiesis; Signal transduction; Cell biology; Genetics; Stem cell; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003958832,0.000480053,0.0003847442,0.0003798427,0.0003028062,0.0003417543,0.0004245021,0.000576049,0.001155018],"category_scores_gemma":[0.0001997739,0.0001905677,0.0003619187,0.0002299165,0.000371933,0.0001943484,0.0002825015,0.001435276,0.0003898981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000539275,"about_ca_system_score_gemma":0.0003463162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00129424,"about_ca_topic_score_gemma":0.001754257,"domain_scores_codex":[0.9995378,0.0001202472,0.0000530563,0.00006141164,0.000105141,0.0001224636],"domain_scores_gemma":[0.9996376,0.00005284727,0.00008064196,0.00004609324,0.00002182883,0.0001609288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004683202,0.0003730651,0.0002085085,0.00003452217,0.000006507801,0.0002704261,0.00002433287,0.000124475,0.9977592,0.0001313894,0.00009330973,0.0005058806],"study_design_scores_gemma":[0.0002555463,0.005016194,0.005756439,0.00001796891,0.00003313576,0.0009561364,0.000110859,0.004090068,0.9805995,0.0001197195,0.003028572,0.00001597597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965631,0.0005238115,0.0009717314,0.000202524,0.0001013595,0.00008392661,0.0004215013,0.00008544939,0.001046491],"genre_scores_gemma":[0.9967504,0.0003276838,0.0008667124,0.00004850426,0.00001497024,0.00007568455,0.0003698343,0.00001440322,0.001531883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00129424,"threshold_uncertainty_score":0.003912747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01504031316133734,"score_gpt":0.2269688193111373,"score_spread":0.2119285061498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}