{"id":"W2980031813","doi":"10.1016/j.chom.2019.08.004","title":"Calcium-Calmodulin-Calcineurin Signaling: A Globally Conserved Virulence Cascade in Eukaryotic Microbial Pathogens","year":2019,"lang":"en","type":"review","venue":"Cell Host & Microbe","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":187,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Korea Food Research Institute; National Research Foundation of Korea; Canadian Institute for Advanced Research; National Cancer Institute; National Institutes of Health; Max and Minnie Tomerlin Voelcker Fund","keywords":"Biology; Virulence; Calcineurin; Calmodulin; Calcium; Microbiology; Calcium signaling; Signal transduction; Pathogenicity; Cell biology; Biochemistry; Enzyme; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005091019,0.001117126,0.001235401,0.001461384,0.0002619554,0.001357061,0.000987248,0.001401723,0.002440655],"category_scores_gemma":[0.0004935697,0.0002289343,0.0003022469,0.001945934,0.0005661263,0.001245184,0.0009101597,0.001952516,0.002560341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008457708,"about_ca_system_score_gemma":0.001365453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008362185,"about_ca_topic_score_gemma":0.001580654,"domain_scores_codex":[0.9998678,0.00001485332,0.0000154264,0.0000314103,0.00005073726,0.00001975103],"domain_scores_gemma":[0.9997815,0.00006788046,0.00003999337,0.000006253533,0.0000642949,0.00004008795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001569261,0.00005112756,0.0001404192,0.01044587,0.00005984912,0.0001874196,0.00003512489,0.0003445895,0.005255881,0.004903362,0.04788136,0.9305382],"study_design_scores_gemma":[0.00002763199,0.00007375034,0.000724067,0.001787536,0.00009836299,0.000658529,0.0000410869,0.0001458653,0.0008553427,0.002488845,0.9930813,0.00001779191],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009981975,0.9982625,0.000179412,0.0003586168,0.0003399049,0.000003175704,0.00002399755,0.00000999831,0.000722488],"genre_scores_gemma":[0.0005961735,0.9979773,0.0001817561,0.0002708334,0.0003513653,0.000004155007,0.00004433272,0.000001448995,0.0005725973],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002440655,"threshold_uncertainty_score":0.008164823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04258363763800245,"score_gpt":0.3021576501112934,"score_spread":0.2595740124732909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}