{"id":"W2980032979","doi":"10.1128/aac.01626-19","title":"Amphotericin B Penetrates into the Central Nervous System through Focal Disruption of the Blood-Brain Barrier in Experimental Hematogenous <i>Candida</i> Meningoencephalitis","year":2019,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Sick Kids Foundation","keywords":"Candida albicans; Meningoencephalitis; In vivo; Blood–brain barrier; Cerebrospinal fluid; Amphotericin B; Pathology; Evans Blue; In vitro; Central nervous system; Bolus (digestion); Medicine; Biology; Microbiology; Surgery; Antifungal; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003291311,0.000393338,0.0003366539,0.0003695366,0.0002433366,0.0002711965,0.0003088329,0.0004357348,0.001438967],"category_scores_gemma":[0.0002326868,0.000204827,0.0002505945,0.0001847264,0.0004791118,0.0004646595,0.0001797621,0.001111384,0.00021285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003208829,"about_ca_system_score_gemma":0.0003306734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001259805,"about_ca_topic_score_gemma":0.001146666,"domain_scores_codex":[0.9997528,0.00006274426,0.00003000431,0.00003856934,0.00003600458,0.00007986207],"domain_scores_gemma":[0.9997886,0.00005324379,0.00005285101,0.00003164118,0.00001850536,0.00005527256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002883926,0.001568595,0.0006538964,0.0001358069,0.0000243443,0.0004602138,0.0001387761,0.0002524181,0.9897721,0.0004749747,0.0001141449,0.003520785],"study_design_scores_gemma":[0.000196959,0.01178725,0.003579138,0.00002618767,0.0000427247,0.0006766227,0.0000993776,0.001133082,0.9815102,0.0001446661,0.0007930153,0.00001081321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979321,0.0007310951,0.0005449664,0.00006202229,0.00002775939,0.00003541883,0.00007182667,0.00001796675,0.0005768004],"genre_scores_gemma":[0.9965282,0.00116848,0.001034434,0.00003962433,0.00001718335,0.00005748549,0.0001440507,0.000008090562,0.001002359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001438967,"threshold_uncertainty_score":0.00481385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007148587216021794,"score_gpt":0.2477103092845292,"score_spread":0.2405617220685074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}