{"id":"W2980034992","doi":"10.1182/blood.v106.11.4261.4261","title":"Pharmacokinetics and Pharmacodynamics of CNTO 528, a Novel Erythropoietin Receptor Agonist in Normal and Anemic Rats.","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Erythropoietin and Anemia Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"","keywords":"Erythropoietin; Erythropoiesis; Pharmacokinetics; Agonist; Reticulocytosis; In vivo; Pharmacodynamics; Anemia; Pharmacology; Medicine; Internal medicine; Endocrinology; Erythropoietin receptor; Receptor; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002605519,0.000488978,0.0004223523,0.0003805627,0.000139616,0.0002457874,0.0002233263,0.0003935392,0.0006635184],"category_scores_gemma":[0.0003708542,0.0002487487,0.0002008237,0.0001801621,0.0003350919,0.0003801812,0.0000782947,0.0008073743,0.000239886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002953069,"about_ca_system_score_gemma":0.0002993585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009494097,"about_ca_topic_score_gemma":0.000847378,"domain_scores_codex":[0.9998688,0.00003997455,0.000007897178,0.00002616897,0.00003030068,0.00002700043],"domain_scores_gemma":[0.9996622,0.00007476419,0.00008953753,0.00003506009,0.00002510739,0.0001133961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02399794,0.003007431,0.001772658,0.00008606645,0.00006450045,0.0001659251,0.00007441933,0.00106711,0.9479897,0.0001811733,0.0004909214,0.02110215],"study_design_scores_gemma":[0.002174636,0.1306446,0.03463528,0.00002214069,0.0003569528,0.0009299198,0.0001479721,0.01152147,0.8130302,0.0002690364,0.006171501,0.00009629067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966432,0.0007871349,0.001374794,0.00005971124,0.00002291498,0.00006320722,0.0003947992,0.0001204238,0.0005339478],"genre_scores_gemma":[0.9952768,0.0008309422,0.001567808,0.00006492702,0.00002681271,0.0001307438,0.0005396978,0.00003118027,0.001530981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009494097,"threshold_uncertainty_score":0.002219677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01085009246891867,"score_gpt":0.2684461842971885,"score_spread":0.2575960918282698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}