{"id":"W2980037177","doi":"10.1186/s13072-019-0298-1","title":"MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2","year":2019,"lang":"en","type":"article","venue":"Epigenetics & Chromatin","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; University of Toronto; Centre for Addiction and Mental Health; Genome British Columbia; Canada's Michael Smith Genome Sciences Centre; University of British Columbia; University of Victoria","funders":"European Social Fund; Instituto de Salud Carlos III; Agència de Gestió d'Ajuts Universitaris i de Recerca; Canadian Institutes of Health Research; Canadian Cancer Society Research Institute; Warren Y. Soper Charitable Trust; Fondation De Famille Alvin Segal; Centro de Investigación Biomédica en Red de Cáncer; Terry Fox Research Institute; Genome British Columbia; Leading Edge Endowment Fund; McGill University; Institució Catalana de Recerca i Estudis Avançats; Jewish General Hospital; Generalitat de Catalunya; European Regional Development Fund; Fundación Cellex; European Commission; Max-Planck-Gesellschaft; Deutsche Forschungsgemeinschaft; University of Victoria; Genome Canada","keywords":"MECP2; Biology; Gene isoform; Rett syndrome; Chromatin; Genetics; DNA; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001242677,0.0003262572,0.0001794251,0.0003335697,0.0001754792,0.0003292632,0.0002024568,0.0003121646,0.001189675],"category_scores_gemma":[0.0002178697,0.000105324,0.0002419556,0.0002520639,0.0002027601,0.000199028,0.0001756077,0.0002827923,0.0003529251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002635527,"about_ca_system_score_gemma":0.0001440037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000721735,"about_ca_topic_score_gemma":0.0009663865,"domain_scores_codex":[0.9998136,0.00001106489,0.00001501063,0.00008572369,0.00004768194,0.00002691136],"domain_scores_gemma":[0.9998442,0.00002455037,0.00006344379,0.00001244505,0.00002522251,0.00003014981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009470678,0.000007560053,0.002849038,0.00004464549,0.00001409776,0.0001892937,0.0000129673,0.00004928674,0.9950863,0.00006578804,0.00006848766,0.001517925],"study_design_scores_gemma":[0.00002120843,0.0001387137,0.1108123,0.00002068941,0.00007960456,0.005494691,0.00008364809,0.001952184,0.8703462,0.000219711,0.0108112,0.00001996699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884639,0.004616912,0.004039021,0.0001341909,0.00004889164,0.00001625043,0.001197374,0.00008205428,0.001401231],"genre_scores_gemma":[0.9914658,0.001113137,0.002721491,0.00009777359,0.0000225698,0.00003001813,0.001719019,0.00003183618,0.002798301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001189675,"threshold_uncertainty_score":0.003979862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006134354215430348,"score_gpt":0.2202078959898032,"score_spread":0.2140735417743728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}