{"id":"W2980037177","doi":"10.1186/s13072-019-0298-1","title":"MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2","year":2019,"lang":"en","type":"article","venue":"Epigenetics & Chromatin","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; University of Toronto; Centre for Addiction and Mental Health; Genome British Columbia; Canada's Michael Smith Genome Sciences Centre; University of British Columbia; University of Victoria","funders":"European Social Fund; Instituto de Salud Carlos III; Agència de Gestió d'Ajuts Universitaris i de Recerca; Canadian Institutes of Health Research; Canadian Cancer Society Research Institute; Warren Y. Soper Charitable Trust; Fondation De Famille Alvin Segal; Centro de Investigación Biomédica en Red de Cáncer; Terry Fox Research Institute; Genome British Columbia; Leading Edge Endowment Fund; McGill University; Institució Catalana de Recerca i Estudis Avançats; Jewish General Hospital; Generalitat de Catalunya; European Regional Development Fund; Fundación Cellex; European Commission; Max-Planck-Gesellschaft; Deutsche Forschungsgemeinschaft; University of Victoria; Genome Canada","keywords":"MECP2; Biology; Gene isoform; Rett syndrome; Chromatin; Genetics; DNA; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008583422,0.000456698,0.0003626531,0.00009782796,0.0001624625,0.0001379467,0.0003536538,0.0001386137,0.0001533549],"category_scores_gemma":[0.00002765339,0.0004036099,0.00008474495,0.0001497356,0.0000981117,0.000009068169,0.0003640992,0.0001655991,0.00006974913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004425181,"about_ca_system_score_gemma":0.0001058942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003286744,"about_ca_topic_score_gemma":0.0003819769,"domain_scores_codex":[0.9977958,0.00006947379,0.0004541886,0.0008162943,0.0003423226,0.0005218957],"domain_scores_gemma":[0.9987892,0.00001394664,0.0001667409,0.0006426961,0.0001119432,0.0002754865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001532487,0.000202833,0.0009512508,0.00009632261,0.00009293581,0.000002580113,0.000343203,0.00004691585,0.9969613,0.00003787131,0.0004223282,0.0006892204],"study_design_scores_gemma":[0.00116791,0.001074046,0.0454541,0.000190584,0.00002870745,0.00001291492,0.0002945201,0.0003909912,0.9411694,0.0001641662,0.009386039,0.0006665644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949168,0.0001654688,0.0009707984,0.0006553291,0.0001004538,0.002063595,0.00008598428,0.00003222635,0.001009349],"genre_scores_gemma":[0.9910876,0.00004248321,0.004961433,0.0003996046,0.00003160934,0.0003473519,0.0001403068,0.00008439757,0.002905246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05579184,"threshold_uncertainty_score":0.9998416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006134354215430348,"score_gpt":0.2202078959898032,"score_spread":0.2140735417743728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}