{"id":"W2980048538","doi":"10.1038/s41467-019-12518-6","title":"N6-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"DOD Prostate Cancer Research Program; Fred Hutchinson Cancer Research Center; Bristol-Myers Squibb; American Cancer Society; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services; Burroughs Wellcome Fund; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; U.S. Department of Defense","keywords":"Erythropoiesis; Biology; Methyltransferase; Gene; Translation (biology); Messenger RNA; H3K4me3; Histone; Gene expression; Genetics; Cell biology; Molecular biology; Methylation; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001891651,0.0001021002,0.0001354183,0.00006311222,0.00020617,0.00001410362,0.0004953422,0.0002624982,0.00001256108],"category_scores_gemma":[0.00006728891,0.0001034373,0.0001315496,0.0001987973,0.0001091435,0.000009093659,0.00006958794,0.0001879071,0.000001807116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002373099,"about_ca_system_score_gemma":0.0000684182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001787924,"about_ca_topic_score_gemma":0.000214656,"domain_scores_codex":[0.9992744,0.00007845308,0.0002240807,0.0002129973,0.0000859611,0.0001241605],"domain_scores_gemma":[0.99819,0.00006272472,0.0001611775,0.001242289,0.0003178473,0.00002599478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003634686,0.0001164939,0.001220803,0.00002818558,0.0001047202,1.21286e-8,0.0001509059,0.00001069915,0.9872117,0.004585218,0.00173359,0.004801336],"study_design_scores_gemma":[0.001837204,0.0006591895,0.02903382,0.00011073,0.0002077446,0.000005656983,0.0003972473,0.000514618,0.7094123,0.002607071,0.2546696,0.000544778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9121628,0.04984225,0.00662922,0.009666081,0.0003519248,0.003344645,0.0004224107,0.0000801605,0.01750048],"genre_scores_gemma":[0.9855627,0.0004874106,0.01250339,0.00006116457,0.00005351095,0.0001328124,0.0006587301,0.00002212609,0.000518175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2777994,"threshold_uncertainty_score":0.421805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02441225145964852,"score_gpt":0.3232691098466526,"score_spread":0.2988568583870041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}