{"id":"W2980054926","doi":"10.14309/01.ajg.0000590392.63444.97","title":"215  Efficacy and Safety of Upadacitinib as an Induction Therapy for Patients With Moderately-to-Severely Active Ulcerative Colitis: Combined Results From 382 Subjects in the Phase 2b Study U-ACHIEVE","year":2019,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Ulcerative colitis; Clinical endpoint; Internal medicine; Placebo; Adverse effect; Gastroenterology; Clinical trial; Surgery; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002514365,0.0005372385,0.00178684,0.0002798511,0.0003219153,0.000573671,0.0003038038,0.0005959552,0.00246744],"category_scores_gemma":[0.001401761,0.0003452608,0.0008854809,0.0004213576,0.0002830539,0.000302462,0.000423787,0.000645993,0.000531689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003305691,"about_ca_system_score_gemma":0.0004912473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004197453,"about_ca_topic_score_gemma":0.0007294912,"domain_scores_codex":[0.998705,0.0007940526,0.00008084612,0.0001474578,0.0001791759,0.00009342829],"domain_scores_gemma":[0.9992251,0.0002451656,0.0001946875,0.00009868944,0.00008776516,0.0001485761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6566489,0.008182845,0.1413075,0.001388306,0.00617101,0.0003859002,0.0003990728,0.001175506,0.03913653,0.00009348529,0.004370629,0.1407403],"study_design_scores_gemma":[0.1374251,0.2286471,0.5999119,0.0001676242,0.008337549,0.001206698,0.0001992428,0.00226078,0.01136303,0.0002342969,0.01013795,0.0001086702],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942092,0.002792079,0.0003124131,0.00008581625,0.0000209527,0.0004284875,0.001210853,0.00003179453,0.0009083551],"genre_scores_gemma":[0.9962422,0.0004638979,0.0004285644,0.0001283388,0.00004749902,0.0003479684,0.001803774,0.000008445602,0.0005293593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002514365,"threshold_uncertainty_score":0.01329738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008318298068470448,"score_gpt":0.2661662122307771,"score_spread":0.2578479141623066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}