{"id":"W2980055023","doi":"10.1182/blood.v126.23.6.6","title":"The Multi-Kinase Inhibitor Midostaurin (M) Prolongs Survival Compared with Placebo (P) in Combination with Daunorubicin (D)/Cytarabine (C) Induction (ind), High-Dose C Consolidation (consol), and As Maintenance (maint) Therapy in Newly Diagnosed Acute Myeloid Leukemia (AML) Patients (pts) Age 18-60 with FLT3 Mutations (muts): An International Prospective Randomized (rand) P-Controlled Double-Blind Trial (CALGB 10603/RATIFY [Alliance])","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Cytarabine; Midostaurin; Medicine; Internal medicine; Gastroenterology; Chemotherapy; Oncology; Surgery; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009600034,0.0008830489,0.001322736,0.0003341693,0.0002588392,0.0006306361,0.0006216695,0.0007483941,0.002093285],"category_scores_gemma":[0.0007368662,0.0003977641,0.0009688326,0.0002664192,0.0008660845,0.0005785779,0.0004051418,0.001927773,0.0003185527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004804694,"about_ca_system_score_gemma":0.0007001441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005285479,"about_ca_topic_score_gemma":0.001368122,"domain_scores_codex":[0.9996867,0.0001732302,0.000022412,0.00004910997,0.00002009481,0.00004844123],"domain_scores_gemma":[0.9994808,0.0001010556,0.0001529196,0.00003392072,0.00001954828,0.0002118737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9480914,0.009583939,0.001866117,0.0002785089,0.0005345132,0.00003422239,0.00005663915,0.0005130193,0.009636591,0.00006791636,0.0005474506,0.02878967],"study_design_scores_gemma":[0.6007046,0.3860058,0.007682157,0.00003433526,0.0007457463,0.0001035352,0.00003277475,0.0006803723,0.003115803,0.0001131745,0.000762414,0.00001923669],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968826,0.001550161,0.0001778993,0.000163892,0.0000904152,0.0004149096,0.0001732917,0.00003840408,0.0005085653],"genre_scores_gemma":[0.9969217,0.000906555,0.0005021485,0.0001983701,0.0001348334,0.0004588783,0.0002199084,0.000007480749,0.000649957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002093285,"threshold_uncertainty_score":0.007002711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03245016808503368,"score_gpt":0.3022962509159641,"score_spread":0.2698460828309304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}