{"id":"W2980055023","doi":"10.1182/blood.v126.23.6.6","title":"The Multi-Kinase Inhibitor Midostaurin (M) Prolongs Survival Compared with Placebo (P) in Combination with Daunorubicin (D)/Cytarabine (C) Induction (ind), High-Dose C Consolidation (consol), and As Maintenance (maint) Therapy in Newly Diagnosed Acute Myeloid Leukemia (AML) Patients (pts) Age 18-60 with FLT3 Mutations (muts): An International Prospective Randomized (rand) P-Controlled Double-Blind Trial (CALGB 10603/RATIFY [Alliance])","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Cytarabine; Midostaurin; Medicine; Internal medicine; Gastroenterology; Chemotherapy; Oncology; Surgery; Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002499745,0.0006860162,0.001588462,0.0005719476,0.0002959353,0.0003340902,0.0003582471,0.0002927981,0.00001988166],"category_scores_gemma":[0.0007930881,0.0004232615,0.00009891904,0.0009877648,0.0009873037,0.0009908543,0.00007833255,0.001114188,0.000007745122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001479024,"about_ca_system_score_gemma":0.001994297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002808203,"about_ca_topic_score_gemma":0.008760114,"domain_scores_codex":[0.9944286,0.00116612,0.001202969,0.001095087,0.001357506,0.0007497726],"domain_scores_gemma":[0.9959947,0.0009076428,0.0007793553,0.000582171,0.001342711,0.000393409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9609457,0.004024558,0.02704691,0.00002566389,0.0009619732,0.0005572562,0.003827944,0.0005028489,0.0009234672,0.0002726961,0.00002582363,0.0008851558],"study_design_scores_gemma":[0.9444584,0.007655719,0.03815255,0.0003359778,0.0003748469,0.00007795972,0.001545538,0.003839959,0.002852503,0.000168363,0.00002918297,0.0005089606],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743197,0.00008367674,0.0003663801,0.001150161,0.0002554036,0.02347338,0.00004735957,0.0001027781,0.0002011591],"genre_scores_gemma":[0.990379,0.0002449375,0.001960085,0.00008949921,0.0001998469,0.005673974,0.001049072,0.0001033499,0.0003002559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0177994,"threshold_uncertainty_score":0.9998219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03245016808503368,"score_gpt":0.3022962509159641,"score_spread":0.2698460828309304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}