{"id":"W2980079371","doi":"10.14309/01.ajg.0000593288.44298.be","title":"938 Positive Results From REGENERATE: A Phase 3 International, Randomized, Placebo-Controlled Study Evaluating Obeticholic Acid Treatment for NASH","year":2019,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Obeticholic acid; Gastroenterology; Internal medicine; Clinical endpoint; Liver biopsy; Population; Placebo; Fibrosis; Intention-to-treat analysis; Biopsy; Randomized controlled trial; Pathology; Agonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001541721,0.001449988,0.002372247,0.0003929819,0.0004422396,0.000809059,0.0006774634,0.001355899,0.006331868],"category_scores_gemma":[0.0008971419,0.0004688972,0.001325618,0.0003344348,0.0006826301,0.0005998042,0.0002903078,0.002309149,0.0008793024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003639785,"about_ca_system_score_gemma":0.0008878062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005506245,"about_ca_topic_score_gemma":0.001442358,"domain_scores_codex":[0.9995899,0.0002099259,0.00002908672,0.00005557699,0.00005274565,0.00006276737],"domain_scores_gemma":[0.9995821,0.00009669874,0.00009958729,0.00003524397,0.00003097606,0.0001553935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9438837,0.01929701,0.0007337514,0.000956071,0.0007226661,0.00007552047,0.00006182646,0.0001758541,0.009763815,0.0001005372,0.001045512,0.02318378],"study_design_scores_gemma":[0.8711061,0.1247679,0.002128461,0.00004466468,0.0003449186,0.00005440076,0.00001932009,0.0001633735,0.0006997907,0.00006449631,0.000596563,0.000009909514],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832798,0.005190788,0.00079054,0.0006711018,0.00036965,0.005659139,0.001525337,0.0001511795,0.002362423],"genre_scores_gemma":[0.9835961,0.004288493,0.001656455,0.001275106,0.000377762,0.004740991,0.001314624,0.00002771139,0.002722725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006331868,"threshold_uncertainty_score":0.02118218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02434667205192506,"score_gpt":0.3547455657095984,"score_spread":0.3303988936576733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}