{"id":"W2980082982","doi":"10.1182/blood.v112.11.243.243","title":"Induction of Immune Tolerance to Canine FVIII in Hemophilia a Dogs with Inhibitors Using AAV-Mediated Expression of Canine FVIII","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Medicine; Genetic enhancement; Immune tolerance; Immunology; Population; Antibody; Immune system; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003393317,0.0002296343,0.0002513372,0.0003626983,0.0001689309,0.0003058433,0.0002167252,0.0004020213,0.001028718],"category_scores_gemma":[0.0003018567,0.0001401718,0.0002289845,0.0001286035,0.0003960297,0.0002658853,0.0001933407,0.0007101616,0.0002356866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003406159,"about_ca_system_score_gemma":0.0001677329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005844494,"about_ca_topic_score_gemma":0.0005278101,"domain_scores_codex":[0.9997881,0.00003316189,0.00002032184,0.00006057061,0.00004518197,0.00005257866],"domain_scores_gemma":[0.9997634,0.00004657301,0.0000898904,0.00002517897,0.00002144226,0.00005351715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003829302,0.0004492051,0.001153921,0.00008272747,0.0000116887,0.0002000218,0.0001292932,0.0002397658,0.9922547,0.0005307786,0.0001763169,0.004388612],"study_design_scores_gemma":[0.0002367985,0.01284337,0.01340555,0.00004260939,0.00009584097,0.003221864,0.0002096606,0.005381886,0.9532051,0.0003184886,0.01101255,0.00002629644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994157,0.0003367657,0.004278661,0.0000718135,0.0000281825,0.00008687934,0.0001008476,0.00009335337,0.0008465747],"genre_scores_gemma":[0.9953136,0.0002389537,0.002670602,0.00005578785,0.00001275852,0.00009861279,0.00020048,0.00002198444,0.001387041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001028718,"threshold_uncertainty_score":0.003441393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02538527281555938,"score_gpt":0.2728987054371672,"score_spread":0.2475134326216078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}