{"id":"W2980088049","doi":"10.1182/blood.v110.11.908.908","title":"A Phase I Trial of Two Sequence-Specific Schedules of Decitabine and Vorinostat in Patients with Acute Myeloid Leukemia (AML).","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Decitabine; Medicine; Tolerability; Mucositis; Vorinostat; Regimen; Internal medicine; Hypomethylating agent; Leukopenia; Neutropenia; Phases of clinical research; Oncology; Gastroenterology; Adverse effect; Pharmacology; Surgery; Toxicity; Histone deacetylase; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001129486,0.001714991,0.00167704,0.0004593368,0.0004156364,0.0006057385,0.0009474114,0.00129076,0.00371022],"category_scores_gemma":[0.0008281092,0.0006233651,0.0009137373,0.0003630247,0.0009558835,0.0007509531,0.0004677073,0.003436319,0.000727989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007945736,"about_ca_system_score_gemma":0.001297164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005618246,"about_ca_topic_score_gemma":0.001323764,"domain_scores_codex":[0.9996552,0.0001427733,0.00002114026,0.00007164736,0.00002948067,0.00007979908],"domain_scores_gemma":[0.9992754,0.0001167013,0.0001502011,0.00005731157,0.00002532841,0.0003750802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7795795,0.06592109,0.003869356,0.0007593067,0.0008561657,0.0002784617,0.0002729461,0.002724355,0.03869202,0.0004923277,0.003595141,0.1029594],"study_design_scores_gemma":[0.6969333,0.2946035,0.003444436,0.00002271323,0.000181139,0.0001940893,0.00003236898,0.0006833838,0.0022376,0.0001535105,0.001497314,0.00001663391],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927124,0.001928558,0.0004708902,0.0005412705,0.000200889,0.002027395,0.000499303,0.00007266786,0.001546751],"genre_scores_gemma":[0.9889686,0.001378349,0.001904088,0.0008616994,0.000275576,0.003066002,0.001492416,0.00001950764,0.002033797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00371022,"threshold_uncertainty_score":0.01241189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01308497506496815,"score_gpt":0.2923354127578263,"score_spread":0.2792504376928582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}