{"id":"W2980110131","doi":"10.1182/blood.v126.23.434.434","title":"A Chromatin Reader That Acts As a Key to Lock in and Coordinate Recruitment of Transcription Factors and a Novel Polycomb Complex to Bivalent Chromatin Thus Driving Formation of Germinal Centers and B-Cell Lymphomas","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"EZH2; Chromatin; Histone methyltransferase; Conditional gene knockout; Biology; Bivalent chromatin; PRC2; Chromodomain; Promoter; Repressor; BCL6; Germinal center; Transcription factor; Cell biology; Genetics; Cancer research; Chromatin remodeling; Gene; B cell; Gene expression; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001165827,0.0002943677,0.0002104951,0.0002066361,0.0002137658,0.0003563662,0.0003482085,0.0002623911,0.003119781],"category_scores_gemma":[0.00009310925,0.0002338862,0.0002283566,0.0001079824,0.0003201673,0.0002395566,0.0005809191,0.0004298442,0.001116148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002596554,"about_ca_system_score_gemma":0.000135578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002093143,"about_ca_topic_score_gemma":0.0004665956,"domain_scores_codex":[0.9998048,0.0000139427,0.0000138398,0.00007639888,0.00005614743,0.0000348901],"domain_scores_gemma":[0.9998758,0.000007058588,0.00002516401,0.00001812063,0.000009947049,0.00006397141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002835903,0.000004343548,0.00008824538,0.000007497195,0.000001521652,0.0000274213,0.000003124446,0.0000165243,0.9992392,0.0001441814,0.00002643743,0.000413141],"study_design_scores_gemma":[0.00001408804,0.00007976074,0.002586141,0.000002044728,0.000005738716,0.0002179628,0.00000920522,0.0009224549,0.9933802,0.00006294544,0.002716136,0.000003405688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9633961,0.00142783,0.02860445,0.0002008728,0.0001420632,0.00006897094,0.0003107585,0.0007270128,0.005121908],"genre_scores_gemma":[0.9853846,0.0001706145,0.005276074,0.0000557088,0.00002026162,0.00003034146,0.0002609531,0.00006097805,0.008740519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003119781,"threshold_uncertainty_score":0.01043665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06482930963498788,"score_gpt":0.2820974495743089,"score_spread":0.217268139939321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}