{"id":"W2980122808","doi":"10.3390/cancers11101519","title":"Transcriptional Modulation by Idelalisib Synergizes with Bendamustine in Chronic Lymphocytic Leukemia","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Canadian Institutes of Health Research; CancerCare Manitoba Foundation; H. Lundbeck A/S; Research Manitoba","keywords":"Idelalisib; Bendamustine; Chronic lymphocytic leukemia; Cancer research; Cytotoxicity; Biology; Cytotoxic T cell; DNA damage; breakpoint cluster region; Leukemia; Molecular biology; Chemistry; Receptor; DNA; In vitro; Immunology; Ibrutinib; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002117717,0.0002729998,0.0003878622,0.000223881,0.0001033682,0.0003552943,0.0001413838,0.0001938883,0.001295952],"category_scores_gemma":[0.0001353788,0.00009710874,0.0002463726,0.0002168631,0.0001580501,0.000127242,0.0001689075,0.0005574439,0.0003194968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003706498,"about_ca_system_score_gemma":0.0002513003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004164748,"about_ca_topic_score_gemma":0.001158117,"domain_scores_codex":[0.9998664,0.00003153254,0.00001239134,0.00001771347,0.00003112166,0.00004091524],"domain_scores_gemma":[0.9999428,0.00001363673,0.000012213,0.000005574546,0.000006813299,0.00001907285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001628292,0.0003769131,0.001234577,0.00009535482,0.0000210239,0.0001069819,0.0000424695,0.0003964671,0.9818611,0.0001084922,0.0003393787,0.013789],"study_design_scores_gemma":[0.0008238491,0.01082946,0.03424375,0.00003045965,0.0001362061,0.0009267238,0.0001239692,0.003105836,0.9298202,0.0001547577,0.01978824,0.00001642326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928032,0.004148504,0.0004539005,0.0001774453,0.00004382063,0.00003555464,0.0003694925,0.0000820805,0.001886003],"genre_scores_gemma":[0.9951709,0.001742163,0.0006144386,0.0001482007,0.000029165,0.00005425334,0.0009016201,0.000017225,0.00132202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001295952,"threshold_uncertainty_score":0.004335403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01129323130428435,"score_gpt":0.2672967940884993,"score_spread":0.256003562784215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}