{"id":"W2980122808","doi":"10.3390/cancers11101519","title":"Transcriptional Modulation by Idelalisib Synergizes with Bendamustine in Chronic Lymphocytic Leukemia","year":2019,"lang":"en","type":"article","venue":"Cancers","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"Canadian Institutes of Health Research; CancerCare Manitoba Foundation; H. Lundbeck A/S; Research Manitoba","keywords":"Idelalisib; Bendamustine; Chronic lymphocytic leukemia; Cancer research; Cytotoxicity; Biology; Cytotoxic T cell; DNA damage; breakpoint cluster region; Leukemia; Molecular biology; Chemistry; Receptor; DNA; In vitro; Immunology; Ibrutinib; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001774664,0.0002090267,0.0003495032,0.0001737624,0.00003647631,0.00002061027,0.0001336241,0.0001299984,0.0008231714],"category_scores_gemma":[0.00002419421,0.000176685,0.00006617239,0.0004726972,0.0001377123,0.0001837244,0.00001957439,0.0002350832,0.0001283781],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.5357898,"about_ca_system_score_gemma":0.1038982,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006983813,"about_ca_topic_score_gemma":0.0005812073,"domain_scores_codex":[0.9980585,0.00003226667,0.0002982801,0.0004625529,0.0006381657,0.0005102113],"domain_scores_gemma":[0.9992235,0.00006874864,0.00006319699,0.0003739462,0.00009300442,0.000177544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002410832,0.00001164182,0.00140416,0.0008773988,0.0001830247,0.0001683263,0.0005606826,0.8848968,0.09826621,0.001034832,0.006658109,0.003527946],"study_design_scores_gemma":[0.04274023,0.0006714372,0.002358545,0.0006416281,0.00005710485,0.0001761157,0.0001621693,0.93418,0.004555991,0.00003530517,0.01409041,0.0003310407],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931527,0.001702966,0.0002137772,0.0001105594,0.000146858,0.000682424,0.00002415307,0.00006963432,0.003896865],"genre_scores_gemma":[0.9941655,0.0002212578,0.0001530349,0.0002490408,0.0001610318,0.00007927795,0.0001639185,0.000048571,0.004758346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4318916,"threshold_uncertainty_score":0.9996288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01129323130428435,"score_gpt":0.2672967940884993,"score_spread":0.256003562784215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}