{"id":"W2980161915","doi":"10.1182/blood.v118.21.2743.2743","title":"Targeting the CML Stem/Progenitor Cell with JAK2 (BMS-911543)/ABL Inhibitor Combination Therapy","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Progenitor cell; Stem cell; Cancer research; Imatinib mesylate; Haematopoiesis; Biology; Tyrosine kinase; Imatinib; Medicine; Immunology; Myeloid leukemia; Cell biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002175475,0.0004791604,0.0006711992,0.0005420405,0.0002120044,0.0004712788,0.0003552494,0.0003597018,0.002149633],"category_scores_gemma":[0.00006049158,0.0001195826,0.0003352561,0.0003760825,0.0001801937,0.0001849233,0.0002288824,0.001044364,0.0006015692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002655488,"about_ca_system_score_gemma":0.0003796114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003017935,"about_ca_topic_score_gemma":0.001366757,"domain_scores_codex":[0.999864,0.00001907149,0.00001075146,0.00001910756,0.00005605097,0.00003110577],"domain_scores_gemma":[0.9999681,0.000003212712,0.000006270958,0.000002649859,0.000004897016,0.00001491306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003827762,0.003349136,0.002373325,0.0005826792,0.0002492945,0.0008638473,0.00008020781,0.001956855,0.7972524,0.001999312,0.003457501,0.1840078],"study_design_scores_gemma":[0.006388796,0.04980876,0.02238315,0.00009503267,0.0009218541,0.004060383,0.0001342876,0.008662046,0.7806002,0.0009496732,0.1259107,0.0000851359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9442629,0.03112442,0.004350962,0.001010575,0.0004860729,0.0008782175,0.000532161,0.0002779968,0.01707663],"genre_scores_gemma":[0.9757701,0.01271293,0.004255126,0.0005782224,0.0002019826,0.0003633563,0.0007585724,0.00002070927,0.005338954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002149633,"threshold_uncertainty_score":0.007191241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02141270312636417,"score_gpt":0.2213805887140572,"score_spread":0.199967885587693,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}