{"id":"W2980164909","doi":"10.1182/blood.v114.22.26.26","title":"In Vitro and In Vivo Mouse Models of the Type 1 Von Willebrand Disease Mutations Y1584C and R1205H.","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Von Willebrand disease; Recombinant DNA; Von Willebrand factor; Molecular biology; ADAMTS13; In vivo; Wild type; Missense mutation; Mutant; Transfection; In vitro; Chemistry; Phenotype; Mutation; Immunology; Biology; Gene; Genetics; Biochemistry; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006624543,0.001336863,0.0004710927,0.001319233,0.000292917,0.0006264664,0.0006273605,0.001591343,0.003853739],"category_scores_gemma":[0.0001985898,0.0005372116,0.0008053776,0.0004080729,0.0004392189,0.0004672566,0.0002773075,0.002083391,0.001775885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005092919,"about_ca_system_score_gemma":0.0002107615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000637214,"about_ca_topic_score_gemma":0.0007918291,"domain_scores_codex":[0.9993718,0.000111267,0.00007592399,0.0001791236,0.0001629825,0.00009899097],"domain_scores_gemma":[0.9995232,0.00008150194,0.0002025632,0.00004952454,0.00003443924,0.0001088456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002950518,0.000309419,0.0001522766,0.00007579075,0.00001859465,0.0002692048,0.00003641047,0.0001552149,0.996996,0.0003517269,0.0002482868,0.001091981],"study_design_scores_gemma":[0.0002181699,0.004298883,0.003469249,0.00004193354,0.0001185497,0.002788861,0.00006474967,0.001688487,0.9788983,0.0002629341,0.008126639,0.00002321794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9632489,0.006243022,0.01516979,0.0007547532,0.0003880711,0.0004032059,0.005941986,0.0008537065,0.006996608],"genre_scores_gemma":[0.9368897,0.006188929,0.01548587,0.0003348704,0.00009527821,0.0007359694,0.007538378,0.0002752936,0.03245564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003853739,"threshold_uncertainty_score":0.01289207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00874531473201642,"score_gpt":0.2355178848598702,"score_spread":0.2267725701278537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}