{"id":"W2980188423","doi":"10.1182/blood.v120.21.291.291","title":"ITIM-Containing Inhibitory Receptors Are Required to Balance Oncogenic Signaling Strength in Ph+ ALL","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"LYN; Receptor; Signal transduction; Biology; Immune system; Immunology; Cell biology; Cancer research; Molecular biology; Tyrosine kinase; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001176289,0.0001998059,0.0001710764,0.0001691981,0.00009384276,0.0003886018,0.0001895511,0.0002337921,0.001679605],"category_scores_gemma":[0.0001833919,0.0001340873,0.0001318898,0.000111263,0.0002386225,0.0001317313,0.0002300902,0.0004252231,0.0004467257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002786464,"about_ca_system_score_gemma":0.0001175362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001946627,"about_ca_topic_score_gemma":0.000196175,"domain_scores_codex":[0.9998652,0.00001892234,0.00001056893,0.00002377534,0.00003516396,0.00004637599],"domain_scores_gemma":[0.9998186,0.00003184774,0.00006458139,0.00001333741,0.0000105906,0.00006101989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001728257,0.00001368233,0.001369869,0.00001532161,0.000002745452,0.00005751197,0.000007992407,0.00005688738,0.9974475,0.00005758717,0.00003088145,0.00076727],"study_design_scores_gemma":[0.0000567918,0.0005421786,0.1107079,0.00001164982,0.00004472893,0.002141189,0.0001465576,0.002872172,0.8809217,0.0002269465,0.002318848,0.00000929975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989198,0.0001776641,0.0003286749,0.00002598442,0.00000332685,0.000006415729,0.0001606059,0.00002670089,0.0003508036],"genre_scores_gemma":[0.9992829,0.00006793375,0.0001883552,0.00001820641,0.000003057659,0.000006598053,0.0001907154,0.000006457705,0.0002357997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001679605,"threshold_uncertainty_score":0.005618811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04128835398626353,"score_gpt":0.3173226627540817,"score_spread":0.2760343087678181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}