{"id":"W2980198391","doi":"10.5114/ada.2019.87454","title":"Arthropathic psoriasis complicated by a paradoxical reaction in the form of erythrodermic psoriasis following adalimumab and by an allergic reaction following infliximab which was successfully managed with secukinumab","year":2019,"lang":"en","type":"article","venue":"Advances in Dermatology and Allergology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Secukinumab; Adalimumab; Psoriasis; Dermatology; Infliximab; Medicine; Paradoxical reaction; Immunology; Psoriatic arthritis; Pathology; Tumor necrosis factor alpha","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004152241,0.0004079764,0.0009238622,0.0002564542,0.000218173,0.00001466715,0.0002852379,0.0006171069,0.00001500082],"category_scores_gemma":[0.00004485199,0.0003148722,0.00008999972,0.0004247008,0.0002859747,0.0006865784,0.00007020204,0.0005129139,0.00001147882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004635301,"about_ca_system_score_gemma":0.00004306519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000256699,"about_ca_topic_score_gemma":0.002949028,"domain_scores_codex":[0.9970326,0.0008726215,0.0006550114,0.0007628289,0.00008939172,0.0005875863],"domain_scores_gemma":[0.9985974,0.0005907717,0.0003116191,0.0004241026,0.00003894953,0.0000370846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01083498,0.002750114,0.6877399,0.0004048848,0.002397466,0.0005841795,0.01243057,0.00008459066,0.2093232,0.003363809,0.0004758759,0.06961048],"study_design_scores_gemma":[0.154842,0.009975888,0.6056941,0.001447501,0.002696008,0.01970195,0.04101665,0.001353523,0.06960029,0.02082968,0.0666317,0.006210716],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818884,0.01590616,0.00006867956,0.0006507516,0.0005090362,0.0005832784,0.00001679722,0.00004977592,0.000327107],"genre_scores_gemma":[0.9948591,0.004310134,0.00007618972,0.000186004,0.00001137458,0.000152012,0.0003396225,0.00002773268,0.00003781348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1440071,"threshold_uncertainty_score":0.9999303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00671683868965513,"score_gpt":0.2398972641719183,"score_spread":0.2331804254822632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}